Evidence map›Paper›PMID 41032219›Full record

ArticleAnnals of nuclear medicine2026

Quantitative analysis of striatal subregional asymmetry on

Danping Wu, Quanfu Jiang, Guoping Shen, Xinting Gao, Chunyi Liu, Wanzhong Ye

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In one paragraph

Article in Annals of nuclear medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The radiotracer [Annals of nuclear medicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Danping WuDepartment of Nuclear Medicine, Jiangyuan Hospital Affiliated to Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, China.
Quanfu JiangDepartment of Nuclear Medicine, Jiangyuan Hospital Affiliated to Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, China.
Guoping ShenDepartment of Nuclear Medicine, Jiangyuan Hospital Affiliated to Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, China.
Xinting GaoDepartment of Nuclear Medicine, Jiangyuan Hospital Affiliated to Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, China.
Chunyi LiuNational Health Commission Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, China.
Wanzhong YeDepartment of Nuclear Medicine, Jiangyuan Hospital Affiliated to Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, China. 13405755505@163.com.ORCID http://orcid.org/0009-0006-1932-973X

Funding

Jiangsu Provincial Medical Key Discipline(Laboratory) ZDXYS202211Soft Science Research Project of Wuxi Science and Technology Association KX-24-B83Youth Science Project of Wuxi Health Committee Q202436
6 · The paper itself

Abstract

objectiveTo investigate the relationship between striatal asymmetry indices-namely the High/Low Ratio and Asymmetry Index (AI)-derived from dopamine transporter single-photon emission computed tomography (DAT-SPECT) using

methodsFifty-six patients with clinically diagnosed PD underwent

resultsPutaminal asymmetry was significantly greater in early-stage PD patients (Hoehn-Yahr ≤ 2; p = 0.010), suggesting early lateralized dopaminergic degeneration. The AI of the caudate nucleus was strongly correlated with UPDRS Part I (non-motor symptoms; r = 0.690, p < 0.001), while putaminal asymmetry was significantly associated with UPDRS Part III (motor symptoms; r = 0.497, p < 0.001).

conclusionRegion-specific DAT-SPECT asymmetry shows domain-specific correlations in PD (caudate-non-motor; putamen-motor). These findings may support the use of TRODAT-1-based imaging biomarkers for precision assessment and individualized management; however, they are hypothesis-generating and require confirmation in larger, better-balanced prospective cohorts.

Indexed as

Organotechnetium CompoundsParkinson DiseaseTomography, Emission-Computed, Single-PhotonTropanesAgedFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedOrganotechnetium Compoundstechnetium Tc 99m TRODAT-1Tropanes99mTc-TRODAT-1Asymmetry indexDopamine transporter imagingHigh/Low ratioParkinson’s diseaseUPDRS subscales

Identifiers

PMID41032219

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.