Evidence map›Paper›PMID 41032102›Full record

ArticleDie Naturwissenschaften2025

Choline hydroxide mediated eco-friendly synthesis of 5-arylidene thiazol-4(5H)-one clubbed coumarin: antimicrobial evaluation and in silico studies.

Muneera S M Al-Saleem, Jehan Y Al-Humaidi, Ahmed A Elhenawy, Sayed M Riyadh, Magdi E A Zaki, Ohoud A Jefri, Sobhi M Gomha

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Article in Die Naturwissenschaften, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Muneera S M Al-SaleemDepartment of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, 11671, Riyadh, Saudi Arabia.
Jehan Y Al-HumaidiDepartment of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, 11671, Riyadh, Saudi Arabia.
Ahmed A ElhenawyChemistry Department, Faculty of Science, AlBaha University, AlBaha, Saudi Arabia.
Sayed M RiyadhDepartment of Chemistry, Faculty of Science, Cairo University, Cairo, 12613, Egypt.
Magdi E A ZakiDepartment of Chemistry, Faculty of Science, Imam Mohammed Ibn Saud Islamic University (IMSIU), 11623, Riyadh, Saudi Arabia. mezaki@imamu.edu.sa.
Ohoud A JefriDepartment of Biological Science, Faculty of Science, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
Sobhi M GomhaDepartment of Chemistry, Faculty of Science, Islamic University of Madinah, 42351, Madinah, Saudi Arabia. smgomha@iu.edu.sa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An efficient and eco-friendly method was developed for synthesizing coumarin-thiazolidinone hybrids using choline hydroxide as a green catalyst. A series of arylidene derivatives (3a-i, 5) were prepared and characterized. Antimicrobial screening against Gram-positive and Gram-negative bacteria, yeast, and fungi demonstrated significant activity, particularly for compound 3c, which produced inhibition zones of up to 30.8 mm against Staphylococcus aureus, and compound 3i, which showed a MIC of 6.25 µg/mL against Escherichia coli, comparable to standard antibiotics. Structure-activity relationship analysis revealed that electron-donating substituents (-OCH₃, indolyl) markedly enhanced potency, while halogen and nitro substituents reduced activity. DFT calculations supported these findings, with 3i showing a low HOMO-LUMO gap (3.183 eV) indicating high reactivity. Molecular docking against Staphylococcus aureus dihydrofolate reductase (PDB: 2XCT) confirmed strong binding, with compound 3c achieving a docking score of -8.6 kcal/mol. These results establish coumarin-thiazolidinone hybrids as promising scaffolds for antimicrobial drug development.

Indexed as

Anti-Infective AgentsCholineCoumarinsHydroxidesBacteriaComputer SimulationFungiGreen Chemistry TechnologyMicrobial Sensitivity TestsMolecular Docking SimulationStructure-Activity RelationshipAnti-Infective AgentsCholinecoumarinCoumarinsHydroxidesAntimicrobial activityCholine hydroxideCoumarin-thiazolidinone hybridsGreen chemistryMolecular dockingStructure activity relationship (SAR)

Identifiers

PMID41032102

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.