Evidence map›Paper›PMID 41031846›Full record

Trial reportNeuropsychological rehabilitation2026

A randomized trial showing mnemonic strategy training increases memory, brain activation, and functional connectivity more than vanishing cue training in cognitively intact older adults.

Benjamin M Hampstead, Alexandru D Iordan, Robert Ploutz-Snyder, Bidisha Ghosh, Ashley Harrie, Anthony Y Stringer, K Sathian

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuropsychological rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Benjamin M HampsteadMental Health Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.
Alexandru D IordanResearch Program on Cognition and Neuromodulation Based Interventions, Departments of Psychiatry & Neurology, University of Michigan, Ann Arbor, MI, USA.
Robert Ploutz-SnyderSystems, Populations and Leadership, Applied Biostatistics Laboratory, University of Michigan, Ann Arbor, MI, USA.
Bidisha GhoshSystems, Populations and Leadership, Applied Biostatistics Laboratory, University of Michigan, Ann Arbor, MI, USA.
Ashley HarrieResearch Program on Cognition and Neuromodulation Based Interventions, Departments of Psychiatry & Neurology, University of Michigan, Ann Arbor, MI, USA.
Anthony Y StringerDepartments of Rehabilitation Medicine, Emory University, Atlanta, GA, USA.
K SathianDepartment of Neurology, Penn State College of Medicine, Hershey, PA, USA.

Funding

Research Program on Cognition and Neuromodulation Based Interventions (RP-CNBI)R35AG072262 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAMPSTEAD, BENJAMIN MICHAEL · 2021 to 2025
$4.2M
NIA NIH HHS R35 AG072262
6 · The paper itself

Abstract

objectivesThis single-blind, parallel groups, randomized controlled trial examined whether (1) mnemonic strategy training (MST) improved memory for face-name associations relative to vanishing cue training (VCT) and (2) the interventions modulated blood oxygen level dependent (BOLD) signal in a training-specific manner.

methodsWe randomized 30 cognitively intact older adults to either MST or VCT (1:1 basis). Memory for face-name associations (primary outcome) was evaluated at baseline and post-training using functional magnetic resonance imaging (fMRI) and again at 1-month follow-up (memory test only). During training sessions, MST participants applied a 3-step strategy while those receiving VCT recalled the targeted name across trials with letters subtracted (correct trials) or added (incorrect trials) as appropriate.

resultsThere were no adverse events and excellent retention. The magnitude of memory test improvement was significantly greater after MST at both post-training and 1-month relative to VCT. The MST group also showed significantly greater BOLD signal changes in multiple brain regions as well as increased functional connectivity between networks relative to the VCT group.

conclusionsMST is superior to VCT for enhancing long-term retention of face-name associations in cognitively intact older adults and appears to enhance use of lateral frontoparietal regions and networks involved in top-down processing.

Indexed as

BrainCuesFacial RecognitionMental RecallAgedAged, 80 and overFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedSingle-Blind Methodagingcognitive rehabilitationCognitive trainingdementiafMRIlearningmemory

Identifiers

PMID41031846
PMCPMC12490805

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.