Evidence map›Paper›PMID 41031843›Full record

ArticleEquine veterinary journal2026

Effectiveness of a screening protocol employed at a UK rescue centre to prevent introduction of strangles.

Luke A McLinden, Jeremy G Kemp-Symonds, Janet M Daly, Adam M Blanchard, Andrew S Waller, Sarah L Freeman

Abstract read
In one paragraph

Article in Equine veterinary journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Luke A McLindenSchool of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK.ORCID https://orcid.org/0000-0001-5858-4721
Jeremy G Kemp-SymondsVeterinary Division, Bransby Horses, Lincoln, UK.
Janet M DalySchool of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK.ORCID https://orcid.org/0000-0002-1912-4500
Adam M BlanchardSchool of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK.ORCID https://orcid.org/0000-0001-6991-7210
Andrew S WallerIntervacc AB, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-7111-9549
Sarah L FreemanSchool of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK.ORCID https://orcid.org/0000-0002-3119-2207

Funding

University of Nottingham as part of an MRes Scholarship
6 · The paper itself

Abstract

backgroundInfection with Streptococcus equi subspecies equi (S. equi) is characterised by acute disease, with about 10% of infected animals remaining persistently infected. Clinically, infection with S. equi cannot readily be distinguished from infection caused by other respiratory pathogens, including Streptococcus equi subspecies zooepidemicus (S. zooepidemicus), equine influenza virus, and equine herpes virus. Screening protocols, with appropriate quarantining facilities, are important to detect horses infected with S. equi and avoid strangles outbreaks. Virulent strains of S. zooepidemicus can also cause strangles-like presentations.

objectivesTo evaluate the effectiveness of the screening process implemented at a UK welfare centre to prevent the introduction of strangles and strangles-like presentations. STUDY

designRetrospective cross-sectional study.

methodsClinical records of 626 equids admitted to a UK welfare centre between 2017 and 2021 and from horses that developed respiratory signs after admission were reviewed. The screening protocol, which included a clinical examination, paired serology samples (iELISA) taken 6 weeks apart, and bilateral guttural pouch endoscopy to identify abnormalities such as chondroids with lavage for qPCR and culture analysis for S. equi (and often S. zooepidemicus) was implemented during this time.

resultsThere were 34 screening-positive equids. Of these, 24 (3.8%) were qPCR-positive for S. equi, 8 were qPCR/culture positive for S. zooepidemicus, and 2 were qPCR/culture negative but had chondroids. Bilateral guttural pouch endoscopy, with qPCR analysis of lavage material, was an effective method of screening equids. There were no cases of strangles or strangles-like presentations within the main herds after screening and admission of new horses. MAIN LIMITATIONS: Variation in the level of detail of clinical records.

conclusionsThe screening process resulted in the identification of screening-positive equids and maintained a strangles-free herd. Further research is required to elucidate the significance of S. zooepidemicus infection in the guttural pouch.

Indexed as

Horse DiseasesMass ScreeningStreptococcal InfectionsStreptococcus equiAnimalsCross-Sectional StudiesFemaleHorsesMaleRetrospective StudiesStreptococcusUnited Kingdomguttural pouchhorsescreeningstranglesStreptococcus equiStreptococcus zooepidemicus

Identifiers

PMID41031843
PMCPMC12892369

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.