Observational studyGeriatrics & gerontology international2025
Association of Serum Creatinine-Cystatin C Ratio With Hospital-Associated Complications and Post-Discharge Mortality.
Observational study in Geriatrics & gerontology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pretreatment creatinine-to-cystatin c ratio as a prognostic marker in digestive tract cancers: a meta-analysis with reconstructed individual patient data and trial sequential analysis.Frontiers in nutrition · 2026Pooled it
- Article
- Association of Serum Creatinine-Cystatin C Ratio With Hospital-Associated Complications and Post-Discharge Mortality.Geriatrics & gerontology international · 2025Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
aimTo examine the associations of serum creatinine-cystatin C ratio (CCR) at admission with mortality at 3 months post-discharge and the incidence of hospital-associated complications (HAC).
methodsThe study was conducted at 2 centers and included patients admitted to and discharged from geriatric wards between October 2019 and July 2023. Patient backgrounds were compared according to mortality at 3 months post-discharge. Next, logistic regression analysis was performed using mortality at 3 months post-discharge as the objective variable. Similarly, logistic regression analysis was performed with the incidence of HAC as the objective variable.
resultsTwo hundred thirty-one patients were included in the analysis. The death group had significantly lower CCR (p < 0.001). In logistic regression analysis adjusted for age and sex, a low CCR was associated with increased mortality (odds ratio 3.260, p = 0.003). This association remained significant even after additional adjustment for kidney function (odds ratio 2.710, p = 0.014). The lowest CCR quartile showed a similar trend with an increased risk of death at 3 months compared to the highest quartile, even after extensive adjustment for demographics, kidney function, comorbidities, frailty, and cognitive function (Odds Ratio 4.157, p = 0.086). On the other hand, no significant association was found between CCR and the incidence of HAC.
conclusionsA low CCR predicted higher post-discharge mortality after basic adjustment; although the association attenuated when frailty and cognition were included, a risk increase persisted for the lowest versus highest quartile. Measuring CCR in hospitalized older adults may be useful for early identification of patients at high risk of death.
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