Evidence map›Paper›PMID 41031527›Full record

ArticleLab on a chip2025

Pressurized photobonding for 3D-printed inertial and droplet microfluidics.

Vivek Rajasenan, Edwin Sanchez Ochoa, Aiden Begole, Amrith Karunaratne, Lisa F Horowitz, Albert Folch, Dino Di Carlo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lab on a chip, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vivek RajasenanDepartment of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, CA, 90095 USA.ORCID http://orcid.org/0009-0009-2616-7216
Edwin Sanchez OchoaDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095 USA. dicarlo@ucla.edu.
Aiden BegoleDepartment of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, CA, 90095 USA.
Amrith KarunaratneDepartment of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, CA, 90095 USA.
Lisa F HorowitzDepartment of Bioengineering, University of Washington, USA.ORCID http://orcid.org/0000-0002-7865-1765
Albert FolchDepartment of Bioengineering, University of Washington, USA.ORCID http://orcid.org/0000-0002-9198-8100
Dino Di CarloDepartment of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, CA, 90095 USA.ORCID http://orcid.org/0000-0003-3942-4284

Funding

Microfluidic Device to Profile Chemosensitivity in Glioma Slice CulturesR01CA181445 · NCI · UNIVERSITY OF WASHINGTON · PI FOLCH, ALBERT · 2014 to 2025
$5.3M
Multiphoton Microscope for Deep Tissue ImagingS10OD025017 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BENTOLILA, LAURENT A. · 2018 to 2018
$599k
NCI NIH HHS R01 CA181445NIH HHS S10 OD025017
6 · The paper itself

Abstract

Microfluidics has transformed scientific and industrial applications by leveraging fluid dynamics at small scales, yet limitations in fabrication techniques continue to impede scalability and design flexibility. This study introduces a novel 3D-printing-based fabrication method, termed "press-cure", which enables the creation of microfluidic devices with high resolution, strong bonds, and solvent resistance using commercially available stereolithography printers. By applying uniform pressure and ultraviolet curing to 3D-printed components, the press-cure method achieves sub-100-micrometer channel dimensions, robust bonding, and structural fidelity under pressures exceeding 300 psi. We demonstrate the versatility of this technique through several microfluidic applications, including scalable step emulsifiers for droplet generation, crescent-shaped particle fabrication, and inertial focusing nozzles. The press-cure method overcomes conventional limitations of PDMS and other fabrication materials, offering enhanced geometric complexity, mechanical robustness, and chemical compatibility. This accessible and scalable approach expands the capabilities of additive manufacturing in microfluidics, paving the way for innovative designs in fields such as flow cytometry, microparticle fabrication, and droplet-based assays.

Identifiers

PMID41031527
PMCPMC12655412

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.