Evidence map›Paper›PMID 41031465›Full record

ArticleClinical endocrinology2026

Urinary Gonadotropins as Markers of Puberty in Girls and Boys During Late Childhood and Adolescence: Evidence From the SCAMP Cohort.

Alexander Spiers, Supitcha Patjamontri, Rachel B Smith, Chen Shen, Mireille B Toledano, S Faisal Ahmed

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Article in Clinical endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Alexander SpiersMRC Centre for Environment and Health, Imperial College London, London, UK.
Supitcha PatjamontriDevelopmental Endocrinology Research Group, Royal Hospital for Children, University of Glasgow, Glasgow, UK.ORCID 0000-0003-1525-8699
Rachel B SmithMRC Centre for Environment and Health, Imperial College London, London, UK.
Chen ShenMRC Centre for Environment and Health, Imperial College London, London, UK.ORCID 0000-0002-0119-4455
Mireille B ToledanoMRC Centre for Environment and Health, Imperial College London, London, UK.
S Faisal AhmedDevelopmental Endocrinology Research Group, Royal Hospital for Children, University of Glasgow, Glasgow, UK.ORCID 0000-0003-0689-5549

Funding

A.S. was supported by a PhD studentship from the Medical Research Council (MRC) (MR/R015732/1).S.P. was funded by the Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. SCAMP is independent research funded (2021-2025) by the Medical Research Council (MRC) (MR/V004190/1), and originally commissioned and funded (March 2014-Dec 2021) by the National Institute for Health Research (NIHR) Policy Research Programme (PRP) (Secondary School Cohort Study of Mobile Phone Use and Neurocognitive and Behavioural Outcomes/091/0212) via the Research Initiative on Health and Mobile Telecommunications (RIHMT) - a partnership between public funders and the mobile phone industry. The SCAMP study is partly supported by the MRC Centre for Environment and Health, which is currently funded by the MRC (MR/S019669/1, 2019-2024). The SCAMP study is also supported by funds from the NIHR Health Protection Research Units in Environmental Exposures and Health & Chemical and Radiation Threats and Hazards, based at Imperial College London, in partnership with UK Health Security Agency (UKHSA) (HPRU-2012-10141). M.B.T.'s Chair, RBS's fellowship and the work in this paper is supported in part by a donation from Marit Mohn to Imperial College London to support Population Child Health through the Mohn Centre for Children's Health and Wellbeing.
6 · The paper itself

Abstract

introductionUrinary gonadotropins measurement is a noninvasive method for evaluation of pubertal development and may have utility in population studies.

objectivesTo investigate the utility of urinary gonadotropins as a noninvasive biomarker of puberty in boys and girls.

methodsSchool-based adolescent cohort study with two time points for collecting school time urine samples and self-reported assessment of puberty through the Pubertal Development Scale (PDS) approximately 2 years apart. FSH and LH were measured by two-site sandwich immunoassay and corrected for creatinine excretion.

resultsA total of 941 samples from 741 girls and 1198 samples from 899 boys aged between 11 and 16 years were analysed. Samples were collected at a median age of 12.3 years (range 11.1, 13.2) and 14.2 years (13.4, 15.7). The annual change for uLH:FSH ratio was +0.028 (95% [0.021, 0.035]) and +0.035 (95% [0.027, 0.043]) in girls and boys, respectively. In a subgroup analysis of 59 samples from girls and 233 samples from boys, collected within 90 days of a PDS, were analysed for correlations with self-reported pubertal development. In girls, uLH:FSH ratio showed positive correlations with self-report breast development (r = 0.29), self-report menarchal status(r = 0.35), composite PDS score (r = 0.39) and PDS-derived pubertal categories (r = 0.45). In boys, uLH:FSH revealed negligible correlations with self-reported pubertal development, PDS composite score and PDS-derived pubertal categories.

conclusionsAn increase in urinary LH:FSH ratio is associated with an increase in self-reported pubertal development in adolescent girls and represents a valid noninvasive biomarker of puberty in population studies.

Indexed as

Follicle Stimulating HormoneGonadotropinsLuteinizing HormonePubertyAdolescentBiomarkersChildCohort StudiesFemaleHumansMaleBiomarkersFollicle Stimulating HormoneGonadotropinsLuteinizing Hormonepubertal developmentpubertal Development Scale (PDS)urinary follicle stimulating hormoneurinary luteinizing hormone

Identifiers

PMID41031465
PMCPMC12669817

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