Evidence map›Paper›PMID 41031417›Full record

ArticleACS infectious diseases2025

Structural Exploitation of Cinnarizine Identified Novel Drug-Like Anthelmintic Agents Against

Bruna L Lemes, Mariana A Siegl-Breno, Mikaelly K Silva-Nunes, Flavia B Lopes, Aline S Silva, Natalia E P Motta, Josué de Moraes, João Paulo S Fernandes

Abstract read
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
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  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bruna L LemesResearch Center on Neglected Diseases, Guarulhos University, Guarulhos 07023-070, Brazil.
Mariana A Siegl-BrenoDepartment of Pharmaceutical Sciences, Federal University of São Paulo, Diadema 09913-030, Brazil.
Mikaelly K Silva-NunesResearch Center on Neglected Diseases, Guarulhos University, Guarulhos 07023-070, Brazil.
Flavia B LopesDepartment of Pharmaceutical Sciences, Federal University of São Paulo, Diadema 09913-030, Brazil.
Aline S SilvaResearch Center on Neglected Diseases, Scientific and Technological Institute, Brazil University, São Paulo 08230-030, Brazil.
Natalia E P MottaDepartment of Pharmaceutical Sciences, Federal University of São Paulo, Diadema 09913-030, Brazil.
Josué de MoraesResearch Center on Neglected Diseases, Guarulhos University, Guarulhos 07023-070, Brazil.ORCID 0000-0003-1766-7031
João Paulo S FernandesDepartment of Pharmaceutical Sciences, Federal University of São Paulo, Diadema 09913-030, Brazil.ORCID 0000-0002-9089-273X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The impact of helminthiases on global health for both humans and animals and the limited efficacy of existing drugs against these infections reinforces the urgent need for novel anthelmintic agents. On this background, in previous work we identified cinnarizine, a first-generation antihistamine, as effective anthelmintic agent against

Indexed as

Angiostrongylus cantonensisAnthelminticsCinnarizineAnimalsHumansLarvaStructure-Activity RelationshipAnthelminticsCinnarizineangiostrongyliasisanthelmintic agentsdrug-likenessmolecular simplification

Identifiers

PMID41031417
PMCPMC12519461

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.