Article in Hypertension (Dallas, Tex. : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors.
Claire A Ruddiman *Robert M. Berne Cardiovascular Research Center (C.A.R., B.L.O., A.W., N.B., L.S.D., A.K.B., B.E.I.), University of Virginia School of Medicine, Charlottesville, VA.
Brooke L O'Donnell *Robert M. Berne Cardiovascular Research Center (C.A.R., B.L.O., A.W., N.B., L.S.D., A.K.B., B.E.I.), University of Virginia School of Medicine, Charlottesville, VA.ORCID 0000-0001-6025-8300
Abigail WolpeRobert M. Berne Cardiovascular Research Center (C.A.R., B.L.O., A.W., N.B., L.S.D., A.K.B., B.E.I.), University of Virginia School of Medicine, Charlottesville, VA.ORCID 0000-0002-4169-3697
Nyla BlagroveRobert M. Berne Cardiovascular Research Center (C.A.R., B.L.O., A.W., N.B., L.S.D., A.K.B., B.E.I.), University of Virginia School of Medicine, Charlottesville, VA.
Luke S DunawayRobert M. Berne Cardiovascular Research Center (C.A.R., B.L.O., A.W., N.B., L.S.D., A.K.B., B.E.I.), University of Virginia School of Medicine, Charlottesville, VA.ORCID 0000-0002-7458-9669
Chien-Jung LinDepartment of Internal Medicine, Cardiovascular Division, SSM-Saint Louis University Hospital, St. Louis, MO (C.-J.L.).ORCID 0000-0002-1702-9411
Angela K BestRobert M. Berne Cardiovascular Research Center (C.A.R., B.L.O., A.W., N.B., L.S.D., A.K.B., B.E.I.), University of Virginia School of Medicine, Charlottesville, VA.
Miriam M Cortese-KrottDivision of Cardiology, Heinrich-Heine University of Düsseldorf, Düsseldorf, Germany (M.M.C.-K.).ORCID 0000-0002-0593-1192
Robert P MechamDepartment of Cell Biology and Physiology (R.P.M.), Washington University, St. Louis, MO.ORCID 0000-0002-4020-9277
Jessica E WagenseilDepartment of Mechanical Engineering and Materials Science (J.E.W.), Washington University, St. Louis, MO.
Brant E IsaksonRobert M. Berne Cardiovascular Research Center (C.A.R., B.L.O., A.W., N.B., L.S.D., A.K.B., B.E.I.), University of Virginia School of Medicine, Charlottesville, VA.ORCID 0000-0002-7692-6294
Funding
Role of Pannexins in Vascular Smooth Muscle CellsP01HL120840 · NHLBI · UNIVERSITY OF VIRGINIA · PI BAYLISS, DOUGLAS A. · 2014 to 2023
$24.0M
BASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Brant E Isakson, Gary K Owens · 1985 to 2026
$19.6M
Purinergic Regulation of Veinous Endothelial PermeabilityR01HL137112 · NHLBI · UNIVERSITY OF VIRGINIA · PI Brant E Isakson, MICHAEL H. KOVAL · 2018 to 2026
$4.7M
Panx1-PIEZO1 Interactions Regulate Renin ReleaseR01HL171997 · NHLBI · UNIVERSITY OF VIRGINIA · PI Brant E Isakson · 2024 to 2026
$2.0M
Iron Regulation of Endothelial Hemoglobin AlphaF32HL172605 · NHLBI · UNIVERSITY OF VIRGINIA · PI DUNAWAY, LUKE STEWART · 2024 to 2024
backgroundEndothelial cells (ECs) are the primary producers of elastin in the internal elastic lamina (IEL) of resistance arteries. These arteries have distinct gaps in their IEL where ECs facilitate heterocellular communication with smooth muscle in a signaling microdomain termed the myoendothelial junction. However, the contribution of the IEL to vasodilation and blood pressure in resistance arteries is not well understood.
conclusionsOur findings suggest that elastin deficiency in resistance arteries alters their vasoreactive properties, resulting in poor contraction and dilation. Furthermore, the absence of the holes in the IEL mislocalizes Hbα and eNOS in resistance arteries, switching the vasodilatory mechanism from endothelial-derived hyperpolarization to NO signaling, mimicking larger conduit arteries.
Indexed as
ElastinEndothelium, VascularVascular ResistanceVasodilationAnimalsBlood PressureEndothelial CellsMaleMiceMice, KnockoutMuscle, Smooth, VascularNitric Oxide Synthase Type IIIElastinNitric Oxide Synthase Type IIIblood pressureelastinendothelial cellshemoglobinvasodilation
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Elastin Regulation of Vasoreactivity in Resistance Arteries. · full record | OpenQuestion