Evidence map›Paper›PMID 41031370›Full record

ArticleiScience2025

Synaptic pruning following NMDAR-dependent LTD preferentially affects isolated synapses.

Côme Camus, Léa Leval, Viviana Villicana-Munoz, Sarka Jelinkova, Benjamin Compans, Frédéric Gambino, Etienne Herzog, Daniel Choquet, Eric Hosy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Molecular Physiology of the Neuronal Synapse.Current issues in molecular biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Côme CamusInterdisciplinary Institute for Neuroscience, University of Bordeaux, CNRS UMR5297, 33000 Bordeaux, France.
Léa LevalInterdisciplinary Institute for Neuroscience, University of Bordeaux, CNRS UMR5297, 33000 Bordeaux, France.
Viviana Villicana-MunozInterdisciplinary Institute for Neuroscience, University of Bordeaux, CNRS UMR5297, 33000 Bordeaux, France.
Sarka JelinkovaInterdisciplinary Institute for Neuroscience, University of Bordeaux, CNRS UMR5297, 33000 Bordeaux, France.
Benjamin CompansInterdisciplinary Institute for Neuroscience, University of Bordeaux, CNRS UMR5297, 33000 Bordeaux, France.
Frédéric GambinoInterdisciplinary Institute for Neuroscience, University of Bordeaux, CNRS UMR5297, 33000 Bordeaux, France.
Etienne HerzogInterdisciplinary Institute for Neuroscience, University of Bordeaux, CNRS UMR5297, 33000 Bordeaux, France.
Daniel ChoquetInterdisciplinary Institute for Neuroscience, University of Bordeaux, CNRS UMR5297, 33000 Bordeaux, France.
Eric HosyInterdisciplinary Institute for Neuroscience, University of Bordeaux, CNRS UMR5297, 33000 Bordeaux, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long-term depression (LTD) is an activity-dependent decrease in synaptic strength. This state initiates either a re-potentiation or a loss, aka pruning, of the synapse within hours to days following its induction. However, the precise relationship between LTD and synaptic pruning remains elusive. Using various imaging techniques and electrophysiology on neuronal cell culture, we reveal a direct relationship between LTD and synaptic pruning. All synapses that exhibit NMDAR-dependent LTD are pruned unless counteracted by input-specific activity. Additionally, we identify the post-synaptic ion channels pivotal for sensing pre-synaptic activity. Finally, we find that neighboring synapses displaying coordinated activity act as mutual safeguards against pruning. These distinctive properties mean that LTD-dependent synaptic pruning has a major impact on synapses that do not contribute to responses involved in network activity.

Indexed as

Cellular neuroscienceMolecular neuroscienceNeuroscience

Identifiers

PMID41031370
PMCPMC12478112

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.