ArticleBioMed research international2025
Sodium Benzoate, Potassium Sorbate, and Citric Acid Food Preservatives Trigger Apoptosis in the Male Reproductive System of Rats.
Article in BioMed research international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Article
- Parental sodium benzoate diet induces fat accumulation in offspring via histone H3K9me3 and SKN-1/Nrf2.Current research in food science · 2026Article
- Sodium Benzoate, Potassium Sorbate, and Citric Acid Food Preservatives Trigger Apoptosis in the Male Reproductive System of Rats.BioMed research international · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The safety of food additives has received significant attention. While individual additives used within specified limits are considered safe, examining the effects of food additives is essential, especially when they are ingested in combination or when consumption exceeds acceptable daily intake levels. In this study, the effects of three common food preservatives-sodium benzoate (SB), potassium sorbate (PS), and citric (Cit) acid-on biochemical markers and histopathology of the male reproductive system were evaluated. Thirty-six male Sprague-Dawley rats received the no observed adverse effect level (NOAEL) doses of SB, PS, and Cit alone or in combination in their drinking water for 8 weeks. Blood samples and the epididymis and testes were surgically collected for analysis. Results showed significant decreases in testicular weight, reduced sperm count and viability, and increased immotile sperm in the SB, PS, and SB + PS groups. These changes were associated with notable decreases in plasma testosterone levels in all treated groups. Elevated lipid peroxidation levels, increased Bax/Bcl-2 ratios, and caspase-3 activity in the combined groups demonstrated induction of apoptosis in testes. Additionally, histopathological analysis revealed degenerative changes in testicular structure and disruption of spermatogenesis. In conclusion, the combined use of these preservatives may lead to reproductive issues in rats, raising concerns about their potential effects on human health.
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Registered trials
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