ArticleCase reports in anesthesiology2025
Charcot-Marie-Tooth Disease With Persistent Perioperative Hypotension due to Autonomic Dysfunction: A Case Report.
Article in Case reports in anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Cardiovascular Autonomic Neuropathy in Charcot-Marie-Tooth Disease: A Genotype-Stratified Study of PMP22 Duplication and GJB1 Mutation Carriers.Journal of the peripheral nervous system : JPNS · 2026Article
- Charcot-Marie-Tooth Disease With Persistent Perioperative Hypotension due to Autonomic Dysfunction: A Case Report.Case reports in anesthesiology · 2025Article
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Authors and funding
2 authors.
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Abstract
Charcot-Marie-Tooth (CMT) is a hereditary neuromuscular syndrome associated with peripheral neuropathy. We describe a case of long-standing CMT disease who underwent general anesthesia for a total knee replacement and developed significant perioperative hypotension. Clinical assessment revealed vasoplegia due to underlying autonomic dysfunction as the most likely cause. Further review also revealed a similar episode of intraoperative hypotension during a previous anesthetic. After failure of conservative strategies, the patient was started on a vasopressor infusion. However, hypotension persisted in the early postoperative period. This case serves to highlight the significance of autonomic dysfunction in CMT patients which can cause perioperative hypotension, a finding that has been rarely reported in the literature. We also discuss current diagnostic modalities that may be useful in managing cases of autonomic dysfunction that may present with hypotension.
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