Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and the risk of early-onset post-stroke depression: a prospective study.

Mingzhu Deng, Kangping Song, Lichen Gao, Zhen Wang, Wei Zhao, Wei Xu, Tieqiao Feng, Fangyi Li

Abstract read

In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

Nonlinear Association Between NHHR and Suicide Attempts in First-Episode Untreated Depression With a Threshold Effect.Depression and anxiety · 2026
Article
Association of higher triglyceride glucose index and triglyceride to high density lipoprotein cholesterol ratio with early-onset post-stroke depression.Scientific reports · 2025
Article
Utility of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio in individuals with retinal vein occlusion.Frontiers in cardiovascular medicine · 2025
Article
Correlations of systemic immune-inflammation index and systemic inflammation response index with the risk for early-onset post-stroke depression in patients with minor stroke: a prospective observational study.Frontiers in neurology
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mingzhu DengDepartment of Neurology, The Second People's Hospital of Hunan Province (Brain Hospital of Hunan Province), Changsha, Hunan, China.

Kangping SongDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.

Lichen GaoDepartment of Pharmacy, School of Pharmacy, Phase I Clinical Trial Centre, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.

Zhen WangDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.

Wei ZhaoDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.

Wei XuDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.

Tieqiao FengDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.

Fangyi LiDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a recently emerging composite biomarker of atherogenic lipid metabolism. However, the relationship between NHHR and early-onset post-stroke depression (PSD) remains underexplored. Methods: Early-onset PSD was diagnosed 2 weeks after an acute ischemic stroke (AIS). Depression severity was assessed using the Hamilton Depression Scale-17 items (HAMD-17). Patients with scores ≥7 were classified into the early-onset PSD group. Spearman rank correlation analysis was used to examine the relationship between NHHR and HAMD scores. Logistic regression analysis was conducted to evaluate the association between NHHR and early-onset PSD. Sensitivity analyses were performed to assess the robustness of the results. The predictive performance of NHHR for early-onset PSD was evaluated using receiver operating characteristic curve (ROC) analysis. Results: Among 846 prospectively enrolled patients, 283 (33.45%) were diagnosed with early-onset PSD. NHHR was positively correlated with HAMD-17 scores ( Conclusion: The findings suggest that NHHR may serve as an independent risk factor for early-onset PSD, providing valuable insights for preventive strategies and prognostic management in these patients.

Indexed as

abnormal lipid metabolismacute ischemic strokedepressionnon-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratiopost-stroke depression

Identifiers

PMID41031193

DOI10.3389/fneur.2025.1645765

PMCPMC12477032

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