Evidence map›Paper›PMID 41031191›Full record

ArticleMaterials today. Bio2025

Realization of differential release of minocycline hydrochloride from electrosprayed polymeric or biomacromolecular microparticles for the repair of traumatic brain injury.

Qingxia Guo, Yue Wang, Manfei Fu, Ziyi Zhou, Xiaopei Zhang, Siyu Chen, Cong Xu, Yuanfei Wang, Tong Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Engineering Silk Fibroin-Based Biomaterials for Neural Repair.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qingxia GuoMedical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266000, China.
Yue WangDepartment of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing, 100000, China.
Manfei FuMedical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266000, China.
Ziyi ZhouDepartment of Plastic and Cosmetic Surgery, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Xiaopei ZhangMedical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266000, China.
Siyu ChenMedical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266000, China.
Cong XuMedical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266000, China.
Yuanfei WangMedical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266000, China.
Tong WuMedical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI) occurs when an external force impacts the brain and can result in various serious consequences. Currently, there are no clinical therapies to satisfy the different pathophysiological stages of TBI, realizing a combination of anti-inflammatories in the acute stage and polarization of M2 phenotype microglia. Herein, poly(lactic-co-glycolic acid) (PLGA) and silk fibroin (SF) were selected as shell layers, respectively, to fabricate minocycline hydrochloride (MH)-loaded core-shell microparticles through coaxial electrospray. MH@SF and MH@PLGA microparticles exhibited a differential release profile to promote nerve repair and regeneration after TBI. MH@SF achieved a fast release in 7 days to suppress neuroinflammatory response, while the sustained release of MH@PLGA up to 25 days allowed for modulating polarization of M2 phenotype microglia. The obtained microparticles promoted cell viability and neurite growth of primary neurons and SH-SY5Y cells by establishing neurite transection (NT) and oxygen-glucose deprivation (OGD) models to simulate primary and secondary injury after TBI.

Indexed as

Differential releaseElectrosprayed microparticleImmune microenvironmentNeuroprotectionTraumatic brain injury

Identifiers

PMID41031191
PMCPMC12478139

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.