Evidence map›Paper›PMID 41031042›Full record

ArticlePeerJ2025

Anticancer potential of ethanolic sidr leaf extracts against MCF-7 breast cancer cells: phytochemical, nutritional, and antimicrobial profile comparisons of different plant parts.

Roqayah H Kadi, Nashi K Alqahtani, Ahmed M Abdulfattah, Fayez Alsulaimani, Ahmed M Basri, Reham M Algheshairy, Hend F Alharbi, Rokayya Sami, Amal Alyamani, Roua S Baty and 6 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Roqayah H KadiDepartment of Biological Sciences, College of Science, University of Jeddah, Jeddah, Saudi Arabia.
Nashi K AlqahtaniDate Palm Research Center of Excellence, King Faisal University, Al Hofuf, Saudi Arabia.
Ahmed M AbdulfattahEmbryonic Stem Cell Unit, King Fahd Medical Research Center, King Abdul Aziz University, Jeddah, Saudi Arabia.
Fayez AlsulaimaniEmbryonic Stem Cell Unit, King Fahd Medical Research Center, King Abdul Aziz University, Jeddah, Saudi Arabia.
Ahmed M BasriEmbryonic Stem Cell Unit, King Fahd Medical Research Center, King Abdul Aziz University, Jeddah, Saudi Arabia.
Reham M AlgheshairyDepartment of Food Science and Human Nutrition, College of Agricultural and Food, Qassim University, Buraydah, Saudi Arabia.
Hend F AlharbiDepartment of Food Science and Human Nutrition, College of Agricultural and Food, Qassim University, Buraydah, Saudi Arabia.
Rokayya SamiDepartment of Food Science and Nutrition, College of Sciences, Taif University, Taif, Saudi Arabia.
Amal AlyamaniDepartment of Biotechnology, Taif University, College of Sciences, Taif, Saudi Arabia.
Roua S BatyDepartment of Biotechnology, Taif University, College of Sciences, Taif, Saudi Arabia.
Ruqaiah I BedaiwiDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.
Hala M Abo-DiefDepartment of Science and Technology, University College-Ranyah, Taif University, Taif, Saudi Arabia.
Nahid A OsmanDepartment of Science and Technology, University College-Ranyah, Taif University, Taif, Saudi Arabia.
Nouf H AlsubhiBiological Sciences Department, College of Science & Arts, King Abdul Aziz University, Jeddah, Saudi Arabia.
Ashwaq M Al-NazawiDepartment of Public Health, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
Manal MalibaryDepartment of Food and Nutrition, Faculty of Human Sciences and Design, King Abdul Aziz University, Jeddah, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Traditional medicine has long utilized natural plants to treat diseases and promote overall health. They have contributed significantly to the creation of modern medications. To supplement existing information, therefore, this current investigation aimed to understand the potential therapeutic properties of the sidr plant against triple negative breast cancer (TNBC) on MCF-7 breast cell line by conducting phytochemical, nutritional, and antimicrobial profile comparisons of different plant parts. Methods: Phytochemical analyses involved soluble sugar composition and oxidation profile, whereas nutritional analysis involved the proximate chemical analysis. Additionally, antimicrobial analyses involved six kings of food-borne bacterial strains. Results: According to the study, leaves possessed the highest amounts of protein (12.44%) and ash (8.17%), as well as the highest amounts of ascorbic acid and total chlorophyll. On the other hand, pulps exhibited the highest flavonoid concentration in their ethanolic extract and had higher sugar contents. Furthermore, at a dosage of 100 µg/mL, the ethanolic extract of leaves showed potent antimicrobial action and suppressed over 50% of MCF-7 breast cancer cell survival. Conclusions: Bioactive components, antioxidant, antimicrobial and nutritional elements of sidr plant appears a promising medicinal candidate to fight breast cancer cells.

Indexed as

Anti-Infective AgentsAntineoplastic Agents, PhytogenicPhytochemicalsPlant ExtractsPlant LeavesAntioxidantsBreast NeoplasmsCell SurvivalFemaleHumansMCF-7 CellsAnti-Infective AgentsAntineoplastic Agents, PhytogenicAntioxidantsPhytochemicalsPlant ExtractsAntimicrobial assesmentsBioactive componentsBreast cancerMCF-7 cellsSidrZiziphus spina-christi (L.)

Identifiers

PMID41031042
PMCPMC12478309

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.