Evidence map›Paper›PMID 41031039›Full record

ArticlePeerJ2025

Integrating network pharmacology, molecular docking, and molecular dynamics simulations to explore potential compounds and mechanisms of

Wanxiang Qi, Bin Shi, Wenqiang Tang, Jiangyong Zeng, Ma Zhuo, Hongcai Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wanxiang QiInstitute of Animal Husbandry and Veterinary Medicine, Xizang Academy of Agriculture and Animal Husbandry Sciences, Lhasa, Xizang, China.
Bin ShiInstitute of Animal Husbandry and Veterinary Medicine, Xizang Academy of Agriculture and Animal Husbandry Sciences, Lhasa, Xizang, China.
Wenqiang TangInstitute of Animal Husbandry and Veterinary Medicine, Xizang Academy of Agriculture and Animal Husbandry Sciences, Lhasa, Xizang, China.
Jiangyong ZengInstitute of Animal Husbandry and Veterinary Medicine, Xizang Academy of Agriculture and Animal Husbandry Sciences, Lhasa, Xizang, China.
Ma ZhuoInstitute of Animal Husbandry and Veterinary Medicine, Xizang Academy of Agriculture and Animal Husbandry Sciences, Lhasa, Xizang, China.
Hongcai MaInstitute of Animal Husbandry and Veterinary Medicine, Xizang Academy of Agriculture and Animal Husbandry Sciences, Lhasa, Xizang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: Active compounds of Results: A total of 24 active compounds were identified, along with 180 overlapping targets related to streptococcal infection. PPI network analysis revealed ten key hub genes, including IL1β, IL6, and MMP9. Enrichment analysis suggested that Conclusion: This study provides mechanistic insights into the multi-component, multi-target, and multi-pathway effects of

Indexed as

CoptisDrugs, Chinese HerbalNetwork PharmacologyStreptococcal InfectionsHumansMedicine, Chinese TraditionalMolecular Docking SimulationMolecular Dynamics SimulationProtein Interaction MapsStreptococcusDrugs, Chinese HerbalCoptis chinensisMolecular dockingMolecular dynamicsNetwork pharmacologyStreptococcus

Identifiers

PMID41031039
PMCPMC12478307

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.