Evidence map›Paper›PMID 41031035›Full record

ArticlebioRxiv : the preprint server for biology2025

The Arp2/3 complex is required for

Summer G Paulson, Isabella Swafford, Fritz W Lischka, Jeremy D Rotty

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Summer G PaulsonUniformed Services University of the Health Sciences, Department of Biochemistry, Bethesda, MD, USA, 20814.ORCID 0000-0002-3488-1817
Isabella SwaffordUniformed Services University of the Health Sciences, Department of Biochemistry, Bethesda, MD, USA, 20814.ORCID 0000-0001-8638-2772
Fritz W LischkaUniformed Services University of the Health Sciences, Department of Anatomy, Physiology, and Genetics, Bethesda, MD, USA, 20814.
Jeremy D RottyUniformed Services University of the Health Sciences, Department of Biochemistry, Bethesda, MD, USA, 20814.ORCID 0000-0002-7782-9672

Funding

Extracellular matrix sensing in cellular signaling, migration and wound repairR01GM134104 · NIGMS · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI ROTTY, JEREMY · 2019 to 2023
$1.6M
NIGMS NIH HHS R01 GM134104
6 · The paper itself

Abstract

Microglia maintain brain homeostasis by performing iC3b-mediated synaptic pruning on excessive dendritic spines during neurodevelopment. Cellular interaction with iC3b is mediated by the Arp2/3 complex in other cell types, but understudied in microglia. Using a combination of

Indexed as

Arp2/3 complexconfined motilityhaptotaxisiC3bMicrogliaphagocytosissynaptic pruning

Identifiers

PMID41031035
PMCPMC12478391

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.