Evidence map›Paper›PMID 41031034›Full record

ArticlebioRxiv : the preprint server for biology2024

Identification of SLC45A4 as a pain gene encoding a neuronal polyamine transporter.

Steven J Middleton, Sigurbjörn Markússon, Mikael Åkerlund, Justin C Deme, Mandy Tseng, Wenqianglong Li, Sana R Zuberi, Gabriel Kuteyi, Peter Sarkies, Georgios Baskozos and 14 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Steven J MiddletonNuffield Department of Clinical Neuroscience, The University of Oxford, Oxford, UK.ORCID 0000-0002-0708-7335
Sigurbjörn MarkússonDepartment of Biochemistry, University of Oxford, Oxford, UK.ORCID 0000-0003-4364-2997
Mikael ÅkerlundDepartment of Clinical Sciences, Lund University Diabetes Centre, Lund University, Lund, Sweden.
Justin C DemeCenter for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, 21702 MD, USA.ORCID 0000-0001-8811-9871
Mandy TsengNuffield Department of Clinical Neuroscience, The University of Oxford, Oxford, UK.ORCID 0000-0002-8388-9292
Wenqianglong LiNuffield Department of Clinical Neuroscience, The University of Oxford, Oxford, UK.ORCID 0009-0002-1043-7639
Sana R ZuberiNuffield Department of Clinical Neuroscience, The University of Oxford, Oxford, UK.ORCID 0000-0002-1589-9448
Gabriel KuteyiDepartment of Biochemistry, University of Oxford, Oxford, UK.
Peter SarkiesDepartment of Biochemistry, University of Oxford, Oxford, UK.ORCID 0000-0003-0279-6199
Georgios BaskozosNuffield Department of Clinical Neuroscience, The University of Oxford, Oxford, UK.
Jimena Perez-SanchezNuffield Department of Clinical Neuroscience, The University of Oxford, Oxford, UK.ORCID 0000-0002-4967-5418
Harry L HébertChronic Pain Research Group, Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, DD1 9SY, Dundee, UK.
Sylvanus ToikumoMental Illness Research, Education and Clinical Center, Crescenz VA Medical Center and Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-6024-0693
Adham FarahNuffield Department of Clinical Neuroscience, The University of Oxford, Oxford, UK.
Susan MaxwellNuffield Department of Clinical Neuroscience, The University of Oxford, Oxford, UK.
Yin Y DongNuffield Department of Clinical Neuroscience, The University of Oxford, Oxford, UK.
Henry R KranzlerMental Illness Research, Education and Clinical Center, Crescenz VA Medical Center and Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-1018-0450
John E LinleyDiscovery UK, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, CB2 0AA, UK.ORCID 0000-0001-6450-8805
Blair H SmithChronic Pain Research Group, Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, DD1 9SY, Dundee, UK.ORCID 0000-0002-5362-9430
Susan M LeaCenter for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, 21702 MD, USA.ORCID 0000-0001-9287-8053
Joanne L ParkerDepartment of Biochemistry, University of Oxford, Oxford, UK.ORCID 0000-0003-2964-2720
Valeriya LyssenkoDepartment of Clinical Sciences, Lund University Diabetes Centre, Lund University, Lund, Sweden.
Simon NewsteadDepartment of Biochemistry, University of Oxford, Oxford, UK.ORCID 0000-0001-7432-2270
David L BennettNuffield Department of Clinical Neuroscience, The University of Oxford, Oxford, UK.ORCID 0000-0002-7996-2696

Funding

Leveraging GWAS Findings to Map Variants and Identify Novel Effector Genes for Alcohol-Related TraitsR01AA030056 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI Struan F A Grant, MATTHEW S KAYSER · 2023 to 2026
$2.5M
BLRD VA I01 BX004820NIAAA NIH HHS R01 AA030056Wellcome Trust
6 · The paper itself

Abstract

Polyamines are regulatory metabolites with key roles in transcription, translation, cell signalling and autophagy

Identifiers

PMID41031034
PMCPMC12478382

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.