Evidence map›Paper›PMID 41030978›Full record

ArticlebioRxiv : the preprint server for biology2025

Lamin A/C Deficiency Drives Genomic Instability and Poor Survival in Small-Cell Lung Cancer through Increased R-loop Accumulation.

Christopher W Schultz, Sourav Saha, Anjali Dhall, Yang Zhang, Parth Desai, Lorinc S Pongor, David A Scheiblin, Valentin Magidson, Yilun Sun, Christophe Redon and 20 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors.

Christopher W SchultzDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Sourav SahaDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Anjali DhallDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Yang ZhangDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Parth DesaiDepartment of Hematology & Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA.
Lorinc S PongorDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
David A ScheiblinOptical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD.
Valentin MagidsonOptical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD.
Yilun SunDepartment of Pharmacology, Physiology, and Drug Development, University of Maryland School of Medicine, Baltimore, MD.
Christophe RedonDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Suresh KumarDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Manan KrishnamurthyDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Henrique B DiasCancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Vasilisa AksenovaDivision of Molecular and Cellular Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.
Elizabeth GiordanoDivision of Molecular and Cellular Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.
Nobuyuki TakahashiDepartment of Medical Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Michael NirulaDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Mohit AroraDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Chiori TabeDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Maria ThomasDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Rajesh KumarDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Yasuhiro ArakawaDepartment of Clinical Pharmacology and Therapeutics, Jikei University School of Medicine, Tokyo, Japan.
Ukhyun JoDevelopmental Therapeutics Branch and Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Beverly A TeicherDivision of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Mirit I AladjemDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Stephen LockettOptical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD.
Mary DassoDivision of Molecular and Cellular Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.
Yves PommierDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Ajit K SharmaDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Anish ThomasDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.

Funding

Investigating the role of neddylation in the repair of topoisomerase I inhibitor-induced replication damage in colorectal cancerR00CA273171 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI Yilun Sun · 2025 to 2026
$498k
Understanding and targeting unique vulnerabilities governing G1/S transition and replication stress in small cell lung cancerR00CA277246 · NCI · TEMPLE UNIV OF THE COMMONWEALTH · PI Christopher William Schultz · 2025 to 2026
$482k
NCI NIH HHS R00 CA273171NCI NIH HHS R00 CA277246
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

agingBiological SciencescancerCell Biologyreplication stressR-loopsSmall Cell Lung Cancer (SCLC)

Identifiers

PMID41030978
PMCPMC12478313

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.