Evidence map›Paper›PMID 41030958›Full record

ArticlebioRxiv : the preprint server for biology2025

High-Affinity, Structure-Validated and Selective Macrocyclic Peptide Tools for Chemical Biology Studies of Huntingtin.

Esther Wolf, Rebeka Fanti, Tatsuya Ikenoue, Justin C Deme, Swati Balakrishnan, Brandon A Keith, Matthew G Alteen, Renu Chandrasekaran, Manisha Yadav, Ritika Bhajiawala and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Esther WolfStructural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
Rebeka FantiStructural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
Tatsuya IkenoueDepartment of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan.
Justin C DemeCenter for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.
Swati BalakrishnanStructural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
Brandon A KeithStructural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
Matthew G AlteenStructural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
Renu ChandrasekaranStructural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
Manisha YadavStructural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
Ritika BhajiawalaStructural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
Suzanne AcklooStructural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
Jia FengDepartment of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Djavad Mowafaghian Centre for Brain Health, Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.
Mahmoud A PouladiDepartment of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Djavad Mowafaghian Centre for Brain Health, Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.
Aled M EdwardsStructural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
Derek WilsonDepartment of Chemistry, York University, Toronto, ON M3J 1P3, Canada.
Susan M LeaCenter for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.
Hiroaki SugaDepartment of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan.
Rachel J HardingStructural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Huntington's disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion in the

Indexed as

HAP40HuntingtinHuntington’s diseaseligand discoverypeptide macrocycles

Identifiers

PMID41030958
PMCPMC12478414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.