ReviewFrontiers in oncology2025
The potential of antibody-drug conjugates in immunotherapy for non-small cell lung cancer: current progress and future.
Review in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Antibody-Drug Conjugates in Lung Cancer: Promise, Progress, and Persistent Challenges.Current issues in molecular biology · 2026Review
- HER2-Mutant Non-Small Cell Lung Cancer Podcast: Knowledge Is Power.Targeted oncology · 2026Article
- Real-world treatment patterns and attrition for non-driver mutation metastatic non-small cell lung cancer in the US.Future oncology (London, England) · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibody-drug conjugates (ADCs) have gained significant attention as a promising therapeutic strategy for non-small cell lung cancer (NSCLC), combining the precision of monoclonal antibodies with the potent cytotoxic effects of chemotherapy. This review summarizes recent advancements in the development of ADCs for NSCLC, focusing on their mechanism of action, key components, and progress in clinical applications. By specifically targeting tumor-associated antigens, ADCs deliver cytotoxic agents directly to cancer cells, thereby enhancing therapeutic efficacy while minimizing systemic toxicity. Several ADCs, such as trastuzumab deruxtecan and sacituzumab govitecan, have shown encouraging results in clinical trials, particularly in tumors with molecular alterations like HER2 and TROP2. Additionally, the combination of ADCs with immune checkpoint inhibitors (ICIs) offers a novel and promising therapeutic avenue, potentially enhancing immune responses and overcoming tumor resistance. Despite these promising outcomes, challenges such as drug resistance, immune evasion, and toxicity persist. The novelty and focus of this article are to discuss the significance of optimizing ADCs design, exploring combination therapies, and enhancing safety management in improving treatment outcomes, with the aim of promoting the research and application of ADCs in the immunotherapy of NSCLC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.