SynthesisFrontiers in oncology2025
The predictive value of PSMA PET/CT in determining pathological upgrading of prostate cancer: A pooling up analysis.
Synthesis in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The diagnostic value of radiomics-based machine learning for lymph node metastasis in prostate cancer: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- ISUP Grade Group Migration Between Prostate Biopsy and Radical Prostatectomy: A Systematic Review of Emerging Predictors.Biomedicines · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The issue of pathological upgrading following radical prostatectomy poses a significant challenge for urologists, and prostate-specific membrane antigen (PSMA) positron emission tomography-computed tomography(PET/CT) has gained increasing prominence as a preoperative assessment tool for patients with prostate cancer in recent years. This study aims to assess the diagnostic accuracy of PSMA PET/CT in predicting pathological upgrading after radical prostatectomy. Methods: We conducted a meta-analysis of diagnostic studies using data from the Cochrane CENTRAL, PubMed, Embase, Scopus, and Web of Science databases through March 2024. We strictly adhered to the guidelines outlined in the PRISMA statement for conducting this diagnostic meta-analysis. We computed the pooled diagnostic accuracy and evaluated heterogeneity while exploring potential sources of heterogeneity through subgroup analysis. Results: A total of 7 studies involving 507 patients were included in the final analysis. All participants had biopsy-confirmed prostate cancer and underwent radical prostatectomy. Prior to surgery, all patients underwent PSMA PET/CT imaging. The pooled diagnostic accuracy yielded a sensitivity of 0.68 (95% CI, 0.60 - 0.76) and specificity of 0.74 (95% CI, 0.59 - 0.85). The area under the summary receiver operating characteristic curve was calculated as 0.74 (95%CI, 0.70 - 0.78). Although heterogeneity was observed, its source remained unclear. Conclusion: The PSMA PET/CT demonstrates a moderate level of accuracy in predicting pathological upgrading following radical prostatectomy, making it a tool with potential clinical application value, particularly in the field of radiotherapy. However, further studies are warranted to enhance its relevance and applicability. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42024503406.
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