Evidence map›Paper›PMID 41030921›Full record

ArticleAggregate (Hoboken, N.J.)2024

The careful selection of zwitterionic nanoparticle coating results in rapid and efficient cell labelling for imaging-based cell tracking.

Nicholas D Calvert, Luciana Yu, Olivia C Sehl, Julia J Gevaert, Natasha N Knier, Angelie Rivera-Rodriguez, Clara S Goulet, Nitara Fernando, Samantha Flood, Carlos M Rinaldi-Ramos and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aggregate (Hoboken, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Nanosystems for delivery of indolicidin peptide.Frontiers in medical technology · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nicholas D CalvertDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, 150 Louis Pasteur Pvt., Ottawa, Ontario, K1N 6N5, Canada.
Luciana YuDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, 150 Louis Pasteur Pvt., Ottawa, Ontario, K1N 6N5, Canada.
Olivia C SehlDepartment of Medical Biophysics, Western University; Imaging Research Laboratories, Robarts Research Institute, London, ON N6A 5B7, Canada.
Julia J GevaertDepartment of Medical Biophysics, Western University; Imaging Research Laboratories, Robarts Research Institute, London, ON N6A 5B7, Canada.
Natasha N KnierDepartment of Medical Biophysics, Western University; Imaging Research Laboratories, Robarts Research Institute, London, ON N6A 5B7, Canada.
Angelie Rivera-RodriguezJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Dr. JG56, P.O. Box 116131, Gainesville FL, 32611, United States of America.
Clara S GouletDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, 150 Louis Pasteur Pvt., Ottawa, Ontario, K1N 6N5, Canada.
Nitara FernandoDepartment of Medical Biophysics, Western University; Imaging Research Laboratories, Robarts Research Institute, London, ON N6A 5B7, Canada.
Samantha FloodDepartment of Medical Biophysics, Western University; Imaging Research Laboratories, Robarts Research Institute, London, ON N6A 5B7, Canada.
Carlos M Rinaldi-RamosDepartment of Chemical Engineering, University of Florida, 1006 Center Dr. P.O. Box 116005, Gainesville Fl, 32611, United States of America.
Paula J FosterDepartment of Medical Biophysics, Western University; Imaging Research Laboratories, Robarts Research Institute, London, ON N6A 5B7, Canada.
Adam J ShuhendlerDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, 150 Louis Pasteur Pvt., Ottawa, Ontario, K1N 6N5, Canada.

Funding

NIH Administrative Supplement to Promote Diversity in Health Related ResearchR01EB031224 · NIBIB · UNIVERSITY OF FLORIDA · PI RINALDI-RAMOS, CARLOS M · 2022 to 2025
$2.4M
NIBIB NIH HHS R01 EB031224
6 · The paper itself

Abstract

The increased clinical application of cell-based therapies has resulted in a parallel increase in the need for non-invasive imaging-based approaches for cell tracking, often through labelling with nanoparticles. An ideal nanoparticle for such applications must be biologically compatible as well as readily internalized by cells to ensure adequate and stable cell loading. Surface coatings have been used to make nanoparticle trackers suitable for these purposes, but those currently employed tend to have cytotoxic effects. Zwitterionic ligands are known to be biocompatible and antifouling, however the head-to-head evaluation of specific zwitterionic ligands for cell loading has not yet been explored. Magnetic particle imaging (MPI) detects superparamagnetic iron oxide nanoparticles (SPIONs) using time varying magnetic fields. Because MPI can produce high contrast, real-time images with no tissue depth limitation, it is an ideal candidate for

Indexed as

cell trackingmagnetic nanoparticle imaging (MPI)nanoparticle functionalizationnanoparticle uptakesurface chemistryzwitterionic ligands

Identifiers

PMID41030921
PMCPMC12478535

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.