ArticleRegenerative biomaterials2025
Co-encapsulation of hepatocytes, mesenchymal stem cells and growth factor in arginine-glycine-aspartate functionalized microbeads for liver disease.
Article in Regenerative biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Injectable microsphere-based delivery strategies for stem cells and their derivatives in tissue regeneration.Bioactive materials · 2026Review
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Authors and funding
5 authors.
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Abstract
Acute liver failure is a life-threatening condition with limited treatment options, primarily liver transplantation, which is constrained by donor shortages and lifelong immunosuppression. This study presents a minimally invasive therapeutic approach using multifunctional microbeads co-encapsulating two cell types: immortalized hepatocytes and umbilical cord-derived mesenchymal stem cells, along with basic fibroblast growth factor-loaded poly(lactide-co-glycolide) microspheres. The alginate microbeads are functionalized with poly(ethylene glycol) and the arginine-glycine-aspartate tripeptide to enhance cell adhesion and are crosslinked via click chemistry for improved structural integrity. The bFGF-loaded PLGA microspheres were synthesized using a double-emulsion solvent evaporation method, achieving an average size of 4.25 ± 2.20 µm, a loading content of 0.078% and an entrapment efficiency of 3.52 ± 0.27%. Sustained bFGF release over 14 days (cumulative 2.39 ± 0.20 ng) enhanced hepatocyte proliferation, human mesenchymal stem cell differentiation and cell viability. Functional assessment demonstrated significantly improved hepatocyte performance, with microbeads producing 2032.53 ± 29.45 ng of albumin and 1057.00 ± 9.19 ng of alpha-fetoprotein over 14 days. Overall, this co-encapsulation strategy enhances hepatocyte regeneration, viability, function and offers a scalable therapeutic platform for ALF. Future studies should optimize the formulation and evaluate long-term efficacy
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