ArticleBrain communications2025
Diagnosis and etiologic classification of optic tract lesions.
Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Existing literature regarding optic tract syndrome, which arises from lesions affecting the optic tract(s), is limited. The objective of this retrospective cohort study was to elucidate the diverse clinical and imaging manifestations of the optic tract syndrome relative to the causative lesion. The study population comprised of all patients with optic tract syndrome who were seen at two tertiary neuro-ophthalmology practices from 2014 to 2024. Inclusion criteria were (i) signs associated with optic tract syndrome (homonymous hemianopia and/or relative afferent pupillary defect and/or characteristic findings on peripapillary optical coherence tomography or ganglion cell analysis) and (ii) radiographically confirmed optic tract lesion. Patient records were ascertained through medical databases and reviewed. Statistical analysis was performed to identify relationships between clinical/imaging manifestations and lesion type. Fifty-six patients with optic tract syndrome were identified. The mean age was 49.4 ± 16.7 years, and 37 were female patients. Aetiologies included space-occupying lesions (
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