ArticleFrontiers in endocrinology2025
Embryo selection at the cleavage stage using Raman spectroscopy of day 3 culture medium and machine learning: a preliminary study.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Background: Blastocyst transfer has been associated with shorter leukocyte telomere length in ART-conceived children, suggesting that extended embryo culture may accelerate aging in offspring. Selecting Day 3 embryos with high developmental potential for transfer could address this issue. The aim of this study is to investigate whether machine learning combined with Raman spectroscopy of spent Day 3 culture medium can serve as a potential method for predicting extended embryo culture outcomes, thereby enabling embryo selection at the cleavage stage. Conclusion: Our preliminary study suggests that machine learning combined with Raman spectra of spent Day 3 culture medium represents a promising non-invasive approach for embryo selection at the cleavage stage.
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