ArticleOphthalmology science2026
Fuchs Endothelial Corneal Dystrophy Associations with Systemic Disease, Lifestyle, and Nutritional Intake.
Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Fuchs' Endothelial Corneal Dystrophy and Cardiometabolic Comorbidities.Ophthalmology · 2026Article
- Metabolic and redox adaptations of the corneal endothelium: From metabolic plasticity to therapeutic opportunities.Redox biology · 2026Review
- Association Between Self-Reported Smoking Behaviour and Fuchs Endothelial Corneal Dystrophy: A Cross-Sectional Analysis.AJO international · 2026Article
Corrections and comments
- Erratum issuedErrata.2026
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To evaluate associations between Fuchs endothelial corneal dystrophy (FECD) and systemic comorbidities, lifestyle factors, and dietary patterns, aiming to identify modifiable risk factors and inform therapeutic strategies. Design: Case-control study integrating a cross-sectional survey with a retrospective chart review conducted at a tertiary referral center. Subjects: The cohort included 100 individuals from the Cornea Service at Massachusetts Eye and Ear Infirmary: 50 patients with FECD and 50 age- and sex-matched controls within a 10-year range. Four controls were excluded due to protocol adherence. Methods: Data collection involved chart reviews and a validated 152-item semiquantitative food frequency questionnaire. Smoking and exercise behaviors were assessed through structured questionnaires. Nutrient intake was adjusted for energy using the residual method. Thus, the energy-adjusted intake estimate is the residual from a regression model in which total energy intake is the independent variable and absolute nutrient intake is the dependent variable. Statistical comparisons included Wilcoxon rank-sum and Fisher exact tests ( Main Outcome Measures: Prevalence and statistical significance of systemic comorbidities, lifestyle behaviors, and dietary intake associated with FECD. Results: Fuchs endothelial corneal dystrophy was associated with hyperlipidemia (74% vs. 50%, Conclusions: Fuchs endothelial corneal dystrophy exhibits significant associations with cardiovascular comorbidities, cumulative tobacco exposure, and specific nutritional factors. The identified associations suggest possible directions for future intervention studies as on cardiovascular management, smoking cessation, and dietary modification. Further studies are warranted to explore mechanistic links and develop preventive and therapeutic strategies. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.