ArticleFood chemistry: X2025
Impact of chitosan on lipid digestion under simulated gastro-intestinal conditions.
Article in Food chemistry: X, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Effects of Dietary Chitosan on Growth, Antioxidant Capacity, Non-Specific Immunity, and Intestinal Health of the Mud Crab,Animals : an open access journal from MDPI · 2026Article
- Influence of dietary fiber type and concentration on pesticide residue bioaccessibility in natural products consumed with emulsified foods.Food chemistry: X · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies demonstrated chitosan's ability to inhibit free fatty acid (FFA) release in emulsions, yet its structural impacts (molecular weight, MW; deacetylation degree, DD) on lipid digestion remained unclear. This study systematically evaluated chitosan variants (MW: 3.2-670 kDa; DD: 71.2-92.5 %) under simulated gastrointestinal conditions. The results revealed that all chitosan formulations suppressed corn oil digestion to varying degrees. Notably, high molecular weight chitosan (670 kDa) with elevated DD (90 %) exhibited the strongest inhibitory activity, reducing the FFA release rate by approximately 77 %. Mechanistically, this resulted from severe emulsion flocculation limiting enzyme access, coupled with enhanced bile salt adsorption (30 % binding) and lipolysis suppression (57 % inhibition). These findings highlight MW/DD as critical determinants of chitosan's lipid-modulating efficacy, offering a strategic basis for designing functional foods targeting controlled nutrient delivery or reduced caloric uptake.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.