ReviewBiochemistry and biophysics reports2025
The research progress of α-ketoglutarate in osteoarthritis.
Review in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Traditional Chinese medicine-derived monomers delay osteoarthritis progression by regulating mitochondrial homeostasis.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
α-Ketoglutarate (AKG) is a key intermediate in the tricarboxylic acid, (TCA) cycle. AKG is not only involved in cellular energy metabolism but also plays important roles in a variety of physiological and pathological processes such as antioxidant activity, anti-inflammatory effects, immune regulation, and maintenance of mitochondrial function, which have garnered widespread attention. Many experiments have shown that there is a certain correlation between AKG and OA. The purpose of this paper is to comprehensively review the literature to elucidate the mechanisms of AKG in alleviating osteoarthritis (OA), such as autophagy, gut microbiota, cellular senescence, and ferroptosis. We aim to provide theoretical references and evidence for the use of AKG in the prevention and treatment of OA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.