ArticleCureus2025
Preliminary Investigation on the Effects of Squeeze-Hold Intervention on Muscle Soreness Relief.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
1 author.
Funding
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Abstract
backgroundDelayed-onset muscle soreness (DOMS) occurs 24-48 hours after exercise and is associated with muscle fiber damage and inflammation. Although various treatments have been proposed, only a few have demonstrated consistent efficacy. This pilot study investigated the immediate effects of squeeze-hold therapy on DOMS using a pneumatic cuff.
methodsTen healthy collegiate students (mean age: 20.8±1.4 years; body mass index: 22.8±2.2 kg/m
resultsMuscle soreness was significantly reduced immediately after the intervention on the treated side (p=0.018). However, this analgesic effect was not sustained, and no significant difference was observed 24 hours later.
conclusionSqueeze-hold intervention produced a transient analgesic effect when applied 24 hours after DOMS-inducing exercise, likely due to reactive hyperemia and gate control mechanisms. However, soreness recurred as inflammatory mediators continued to be produced. Repeated application during the 24-48-hour period, when CRP remains elevated, may provide more consistent pain relief.
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