ArticleCureus2025
Effect of Topical Application of Povidone-Iodine on the Number of Bacteria Entering the Lower Respiratory Tract of Intubated Patients: A Randomized Controlled Trial.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of the study was to evaluate and compare the efficacy of povidone-iodine (PI) oral care and toothbrushing in reducing the number of viable bacteria in subglottic secretions of intubated patients.
methodsThis open-label randomized controlled trial included 20 ICU patients undergoing mechanical ventilation. Patients were assigned to either the PI or the toothbrushing groups. Subglottic secretions were collected immediately before oral care (baseline) and at 1, 2, 3, and 6 hours after the intervention. Viable bacterial counts were quantified using delayed real-time polymerase chain reaction. The Mann-Whitney U test was used for statistical comparison.
resultsThe PI group showed significant reductions in bacterial counts at 2, 3, and 6 hours after care (p=0.023, 0.002, and <0.001, respectively), whereas the toothbrushing group did not show significant changes.
conclusionPI oral care effectively reduces viable bacterial load in the lower respiratory tract and may serve as a safe and cost-effective alternative to chlorhexidine for ventilator-associated pneumonia prevention in Japan.
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