ReviewHealth science reports2025
Epidermal Keratinocyte Cells in Laboratory, Clinical Trials, and Market: A Narrative Review.
Review in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Chemogenetic Activation of GFASEB bioAdvances · 2026Article
- Development of a Carprofen-Loaded Nanoemulsion for Topical Management of Post-Surgical Inflammation.Pharmaceutics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: The skin serves essential protective and regulatory functions. In severe injuries such as burns, keratinocytes-being the main epidermal cells-play a pivotal role in skin regeneration through secretion of growth factors and cytokines. This review explores the biology of keratinocytes and their application in treating skin disorders and developing skin substitutes. Methods: A comprehensive literature review was conducted, analyzing studies on the therapeutic use of allogeneic and autologous keratinocytes in wound healing and skin regeneration. Research on cultured epidermal substitutes, including keratinocyte-based grafts and engineered skin constructs, was also reviewed. Results: Findings indicate that autologous keratinocyte transplantation-such as auto-dermatoplasty using a patient's own skin-has been highly effective in treating extensive burns and postsurgical wounds. However, in cases where sufficient donor skin is unavailable, alternative approaches such as keratinocyte culture combined with collagen gel and fibroblasts have shown promising results. Clinical studies demonstrate that epidermal keratinocyte-based therapies significantly reduce scarring, enhance wound healing, and improve survival rates in patients with severe burns. Conclusion: Given their high proliferation capacity, accessibility, and ability to differentiate into epidermal layers, keratinocytes represent a valuable tool for tissue engineering and regenerative medicine. Future advancements in keratinocyte-based therapies and bioengineered skin substitutes hold significant potential for improving outcomes in patients with critical skin injuries.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.