ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Variation in depression's impact on dementia risk by age in adults aged ≥75 years.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Cognitive Impairment, Dementia and Depression in Older Adults.Journal of clinical medicine · 2026Review
- Clinical Depression in the Last Year in Life in Persons Dying from Non-Cancer Conditions-Real World Data.Diseases (Basel, Switzerland) · 2025Article
- Variation in depression's impact on dementia risk by age in adults aged ≥75 years.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLate-life depression is linked to an increased dementia risk; however, whether this relationship varies with age remains unclear.
methodsWe analyzed data from 1,127,331 individuals aged ≥75 years without dementia from the Korean National Health Insurance database who had undergone health screening between 2012 and 2015. Participants were followed up for ≤10 years. Cox proportional hazards and Fine-Gray subdistribution models were used to estimate dementia risk.
resultsDepression was associated with increased dementia risk in both the old-old (75 to 84 years; hazard ratio [HR]: 1.338, 95% confidence interval [CI]: 1.325 to 1.351) and the oldest-old (≥85 years; HR: 1.111, 95% CI: 1.071 to 1.152), with attenuated effects at older ages. Cerebrovascular disease modified this association in the old-old, but no interaction was observed in the oldest-old. DISCUSSION: Depression's impact on dementia risk decreases with age. Cerebrovascular diseases may influence depression-associated neurodegenerative pathways, although this interaction diminishes in the oldest-old. Highlights: Depression increased dementia risk in adults aged 75 years and older.The strength of the association declined with advancing age.Effect modification by cerebrovascular disease was observed only in the 75 to 84 old group.Findings support age-related decline in depression's impact on dementia risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.