Evidence map›Paper›PMID 41030465›Full record

ArticleAmerican journal of preventive cardiology2025

Is spontaneous preterm delivery associated with impaired arterial stiffness at 6 months postpartum?

Margo B Minissian, Sarah Kilpatrick, Odayme Quesada, Jo-Ann Eastwood, Kathryn J Sharma, Chrisandra L Shufelt, Janet Wei, Lynn V Doering, Leah Spiro, Michael Luu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of preventive cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Margo B MinissianBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Sarah KilpatrickDepartment of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Odayme QuesadaDepartment of Non-Invasive Cardiology, The Christ Hospital Health Network, USA.
Jo-Ann EastwoodUniversity of California Los Angeles, School of Nursing, CA, USA.
Kathryn J SharmaCentral Coast Perinatology, Santa Barbara, CA, USA.
Chrisandra L ShufeltWomen's Health Research Center and Division of General Internal Medicine, Mayo Clinic, Jacksonville, FL, USA.
Janet WeiBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Lynn V DoeringUniversity of California Los Angeles, School of Nursing, CA, USA.
Leah SpiroGeri and Richard Brawerman Nursing Institute, Cedars-Sinai Health System, Los Angeles, CA, USA.
Michael LuuDepartment of Biostatistics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Galen Cook WiensDepartment of Biostatistics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
C Noel Bairey MerzBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Funding

Hypertensive Disorders of Pregnancy: Pathways to Future Cardiovascular DiseaseK23HL151867 · NHLBI · THE CHRIST HOSPITAL · PI QUESADA, ODAYME · 2020 to 2024
$799k
Identifying Inflammatory and Endothelial Mechanisms promoting Cardiac Deformation in Women with a History of PreeclampsiaR03HL177034 · NHLBI · THE CHRIST HOSPITAL · PI Odayme Quesada · 2025 to 2026
$198k
NHLBI NIH HHS K23 HL151867NHLBI NIH HHS R03 HL177034
6 · The paper itself

Abstract

Background: Spontaneous preterm delivery (sPTD) is associated with increased risk of cardiovascular disease (CVD), but the mechanistic pathways are not understood. Objectives: Assess arterial wave reflection and stiffness over time in women with sPTD compared to term delivery. Methods: A prospective study comparing women with sPTD (gestation age [GA] ≤ 34 weeks) to matched controls (GA ≥ 39 weeks). Data collected at 24-72 hours ( Results: Mean GA for sPTD and controls were 30.8 weeks and 39.6 weeks, respectively. Mean maternal age for sPTD was 33 ± 6 years, controls was 32 ± 6 years. Change in vascular function among controls demonstrated significantly lower AIx75 at 6 months postpartum compared to 24-72-hour postpartum [Δ: -14.10, 95 % CI: -21.41- (-6.78), Conclusions: Women with sPTD had no significant change in AIx75 while term delivery demonstrated significant decreases at 6 months postpartum. This may contribute to mechanistic pathway and future CVD risk understanding for women with sPTD. Further research is warranted to assess if the physiology of full-term pregnancy is beneficial in augmenting vascular function, demonstrating that the timing of delivery is not a confounding variable.

Indexed as

Adverse pregnancy outcomesCardiovascular diseaseSpontaneous preterm deliveryVascular function

Identifiers

PMID41030465
PMCPMC12478130

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.