ArticleClinical, cosmetic and investigational dermatology2025
Identification and Validation of Hub Genes in Hidradenitis Suppurativa.
Article in Clinical, cosmetic and investigational dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Hidradenitis suppurativa (HS) is a severe, chronic inflammatory disease characterized by inflammatory nodules, progressive sinus tracts, and fistulas. Currently, its pathogenesis remain incompletely understood, and while diverse treatments are available, these have suboptimal efficacy. Herein, we analyzed the relevant genes and pathways in HS using bioinformatics to provide directions for the development of novel treatment. Methods: Two HS datasets were obtained, and differentially expressed genes associated with HS were identified. Enrichment analysis was performed, and a protein-protein interaction network of differential genes was produced. Genes were analyzed using the CytoHubba plugin to obtain the hub genes. For validation, we analyzed the differentially expressed genes between the affected skin tissues of patients with HS and normal human skin tissues. Results: Overall, 180 differential genes associated with HS were identified. Differentially expressed genes were mainly enriched in leukocyte migration, serine hydrolase activity, and serine-type peptidase activity. In total, 69 transcription factors, 115 microRNAs, and 41 drugs associated with hub genes were identified. The expression of Conclusion: Ten hub genes were identified. Among these,
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