Evidence map›Paper›PMID 41030457›Full record

ArticleFrontiers in immunology2025

Modified recombinant collagen-peptide/gallic acid grafted chitosan composites with antibacterial and antioxidant property for wound dressing: a preliminary study.

Yu Chen, Wenjie Wen, Jie Wang, Shiting Huang, Qianqian Ren, Jiayao Cai, Songlin Zhou, Rui Li, Dandan Ren, Liaotian Peng and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yu Chen *Anhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Wannan Medical College, Wuhu, China.
Wenjie Wen *Anhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Wannan Medical College, Wuhu, China.
Jie Wang *Anhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Wannan Medical College, Wuhu, China.
Shiting HuangAnhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Wannan Medical College, Wuhu, China.
Qianqian RenAnhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Wannan Medical College, Wuhu, China.
Jiayao CaiAnhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Wannan Medical College, Wuhu, China.
Songlin ZhouAnhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Wannan Medical College, Wuhu, China.
Rui LiAnhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Wannan Medical College, Wuhu, China.
Dandan RenAnhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Wannan Medical College, Wuhu, China.
Liaotian PengSchool of Laboratory Medicine, Wannan Medical College, Wuhu, China.
Chao DengAnhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Wannan Medical College, Wuhu, China.
Jue ZhangAnhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Wannan Medical College, Wuhu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic wounds pose a persistent clinical challenge, primarily due to prolonged bacterial infections. The development of natural antibacterial dressings offers a promising strategy for their effective management. In this study, recombinant human collagen methacrylamide (RHCMA) and gallic acid-grafted chitosan (CSGA) were synthesized and subsequently crosslinked via UV irradiation to form a composite hydrogel (RHCMA-CSGA). The composition and structure of the hydrogel were systematically characterized. Its cytocompatibility and antibacterial properties were also evaluated. The results demonstrated that the hydrogel exhibited excellent biocompatibility and strong antibacterial activity. These findings suggest that the RHCMA-CSGA hydrogel holds great potential as a therapeutic dressing for chronic wound healing.

Indexed as

Anti-Bacterial AgentsAntioxidantsBandagesChitosanCollagenGallic AcidPeptidesWound HealingAnimalsHumansHydrogelsRecombinant ProteinsAnti-Bacterial AgentsAntioxidantsChitosanCollagenGallic AcidHydrogelsPeptidesRecombinant Proteinsantibacterial propertyantioxidantsrecombinant collagen-peptideRHC based hydrogelwound repair

Identifiers

PMID41030457
PMCPMC12477194

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.