ArticleSurgical neurology international2025
Neuropsychiatric outcomes in responsive neurostimulation: A single-center experience.
Article in Surgical neurology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
Background: Responsive neurostimulation (RNS) is an emerging technology for treating drug-resistant epilepsy (DRE). While seizure outcomes are well-documented, there is a paucity of literature evaluating the postoperative neurocognitive effects of RNS implantation in epilepsy patients utilizing the comprehensive neuropsychological tests often performed in pre-surgical evaluations. We compared pre- and post-RNS implantation neuropsychological evaluation results to elucidate neurocognitive changes. Methods: We retrospectively reviewed charts of DRE patients who received RNS implants at our institution between 2017 and 2024 who underwent both pre- and post-operative neuropsychiatric evaluations. Evaluations included general abilities, attention, memory, language, visual-spatial/construction naming, executive function, and motor skills. Statistical significance was set at Results: We included 14 patients, and their mean age at RNS implantation was 39.1 years. The median seizure reduction in our cohort was 75%, with a 100% responder rate. The mean follow-up time for postoperative neuropsychiatric evaluation was 14.3 months. The vast majority of paradigms demonstrated no significant change. There was a small statistically and clinically significant reduction in the AMNART premorbid estimate (Mean change: -2.07, Conclusion: RNS was not associated with significant changes across multiple neuropsychology paradigms and may help attenuate the progressive neurocognitive decline often seen in DRE patients. Future research is needed to elucidate these trends further.
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