Evidence map›Paper›PMID 41030382›Full record

ArticleJBMR plus2025

Neutralization of Receptor activator of nuclear factor-κB ligand reduces fibrosis and promotes osteoblast differentiation in a mouse model of fibrous dysplasia driven by somatic expression of

Renee T Ormsby, Yongxing Zhang, Cole Hodys, Lella A Wake, Samantha Menendez Perez, Kelly Tsang, Yingzi Yang, Julia F Charles

Abstract read
In one paragraph

Article in JBMR plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Renee T OrmsbyDepartment of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA, 02115, United States.ORCID https://orcid.org/0000-0002-0673-5791
Yongxing ZhangDepartment of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA, 02115, United States.
Cole HodysDepartment of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA, 02115, United States.
Lella A WakeDepartment of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA, 02115, United States.
Samantha Menendez PerezDepartment of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA, 02115, United States.
Kelly TsangDepartment of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA, 02115, United States.
Yingzi YangHarvard School of Dental Medicine, Boston, MA, 02115, United States.
Julia F CharlesDepartment of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA, 02115, United States.ORCID https://orcid.org/0000-0002-5875-314X

Funding

Gas-Hedgehog signaling in intramembranous bone formation and expansionR01DE025866 · NIDCR · HARVARD MEDICAL SCHOOL · PI Yingzi Yang · 2016 to 2026
$5.3M
Osteoclasts or RANKL: Which is the critical target in treatment of fibrous dysplasia bone lesions?R21AR080849 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI CHARLES, JULIA F · 2024 to 2025
$404k
NIAMS NIH HHS R21 AR080849NIDCR NIH HHS R01 DE025866
6 · The paper itself

Abstract

Fibrous dysplasia (FD) is a rare disorder caused by somatic activating mutations in

Indexed as

fibrosisfibrous dysplasiaosteoclastosteoprogenitorRANKLSMA

Identifiers

PMID41030382
PMCPMC12478024

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.