Evidence map›Paper›PMID 41030325›Full record

ArticleJournal of diabetes research2025

Single-Cell RNA Sequencing Shows Exercise Protects

Wenya Weng, Manjuan Li, Zixuan Wang, Mengmeng Peng, Guoyong Fan, Shicui Jiang, Chi Zhang, Xuemian Lu

Abstract read
In one paragraph

Article in Journal of diabetes research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenya WengDepartment of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou City, Zhejiang Province, China.ORCID https://orcid.org/0000-0002-9368-0556
Manjuan LiDepartment of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou City, Zhejiang Province, China.ORCID https://orcid.org/0009-0004-5629-5677
Zixuan WangDepartment of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou City, Zhejiang Province, China.
Mengmeng PengDepartment of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou City, Zhejiang Province, China.ORCID https://orcid.org/0000-0003-4528-6981
Guoyong FanDepartment of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou City, Zhejiang Province, China.ORCID https://orcid.org/0009-0000-1612-054X
Shicui JiangDepartment of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou City, Zhejiang Province, China.ORCID https://orcid.org/0000-0001-8067-415X
Chi ZhangDepartment of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou City, Zhejiang Province, China.ORCID https://orcid.org/0000-0002-3717-7665
Xuemian LuDepartment of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou City, Zhejiang Province, China.ORCID https://orcid.org/0009-0004-7525-5689

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence and mortality rates of Type 2 diabetes mellitus (T2DM) continue to increase, imposing a significant burden on individuals and nations worldwide. The pancreas plays an important role in T2DM development, while exercise is a crucial nonpharmacological treatment. Although the pancreas comprises various cell types, current studies on the effects of exercise on diabetes have mainly focused on the beta cells. In this study, we aimed to enhance our understanding of the effects of exercise on other pancreatic cell types. This was aimed at facilitating the comprehensive analysis of the processes and principles by which exercise protects and enhances pancreatic function. Six-week-old male

Indexed as

Diabetes Mellitus, Type 2Endothelial CellsHomeostasisPancreasPhysical Conditioning, AnimalAnimalsInsulin-Secreting CellsMaleMiceMice, Inbred C57BLSequence Analysis, RNASingle-Cell Analysiscapillary endothelial cellsinterval aerobic trainingnonpharmacological treatmentType 2 diabetesvascular development

Identifiers

PMID41030325
PMCPMC12479157

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.