Evidence map›Paper›PMID 41030312›Full record

ArticleRSC medicinal chemistry2025

Pan-cancer analysis reveals HMOX1 as a cancer prognosis and immune infiltration-related biomarker.

Yingli Men, Hui Wang, Xiaoyan Xu, Miling Yang, Ruiting Feng, Jizhi Zhao, Ying Liu, Lu Yang, Yinsen Song, Cong Ding

Abstract read
In one paragraph

Article in RSC medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yingli MenTranslational Medicine Research Center, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People's Hospital) Zhengzhou Henan China df13607670608@163.com.
Hui WangTranslational Medicine Research Center, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People's Hospital) Zhengzhou Henan China df13607670608@163.com.
Xiaoyan XuDepartment of Pathology, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People's Hospital) Zhengzhou Henan China.
Miling YangDepartment of Pathology, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People's Hospital) Zhengzhou Henan China.
Ruiting FengTranslational Medicine Research Center, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People's Hospital) Zhengzhou Henan China df13607670608@163.com.
Jizhi ZhaoTranslational Medicine Research Center, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People's Hospital) Zhengzhou Henan China df13607670608@163.com.
Ying LiuTranslational Medicine Research Center, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People's Hospital) Zhengzhou Henan China df13607670608@163.com.
Lu YangTranslational Medicine Research Center, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People's Hospital) Zhengzhou Henan China df13607670608@163.com.
Yinsen SongTranslational Medicine Research Center, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People's Hospital) Zhengzhou Henan China df13607670608@163.com.
Cong DingRespiratory and immune Diseases Laboratory, Children's Hospital Affiliated to Zhengzhou University 33 Longhu Waihuan East Road Zhengzhou Henan 450018 P.R. China dingcong8866@163.com.ORCID https://orcid.org/0000-0001-9449-685X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HMOX1 has gained increasing recognition across multiple malignancies; however, its precise oncogenic or tumor-suppressive roles remain incompletely defined. In this study, we comprehensively investigated HMOX1 across diverse tumor types utilizing the cancer genome atlas (TCGA). We further integrated data from multiple bioinformatics platforms, including TIMER2, UALCAN, GEPIA2, cBioPortal, R, GSCA, and LinkedOmics. Western blotting and quantitative real-time PCR (qRT-PCR) confirmed differential HMOX1 expression between normal renal epithelial cells and KIRC cells. Functional assays

Identifiers

PMID41030312
PMCPMC12478454

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.