ArticleBioengineering & translational medicine2025
A silicon membrane microfluidic oxygenator for use as an artificial placenta with minimal anticoagulation.
Article in Bioengineering & translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Physiology-Mimicking Microfluidic Oxygenator with Good Hemocompatibility forMicromachines · 2026Article
- Characterization of PEG-Modified Composite Membranes for Microfluidic Oxygenator Applications.Micromachines · 2025Article
- A silicon membrane microfluidic oxygenator for use as an artificial placenta with minimal anticoagulation.Bioengineering & translational medicine · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Extreme prematurity carries a high burden of morbidity and mortality. The artificial placenta is an emerging therapy that has the potential to improve outcomes in these patients. However, current devices in development are limited by inadequate hemocompatibility, a major barrier to the translation of the artificial placenta into humans. Here, we present a novel microfluidic oxygenator that is comprised of a stacked array of semiconductor silicon membranes and operates with minimal anticoagulation (activated clotting time = 120-180 s). We describe the design, construction, and testing of two generations of prototypes. Our Generation 2 Device had an oxygen transfer of 1.51 ± 0.25 volume % (mean ± standard error). Computational fluid dynamics (CFD) modeling demonstrated favorable blood flow properties, including laminar flow, no stasis or recirculation, and optimal wall shear stress. In vivo testing in a 6 hour neonatal swine model showed that the silicon membrane oxygenator could operate with low-dose anticoagulation with minimal clot formation. Furthermore, the oxygenator had no significant effect on markers of animal health, including inflammation (white blood cell count), coagulation (platelet count, prothrombin time), or hemolysis (hematocrit, plasma free hemoglobin). This study represents a key advance toward developing an anticoagulation-free oxygenator and ultimately bringing artificial placenta technology to patients.
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Registered trials
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