Evidence map›Paper›PMID 41030275›Full record

ArticleBioengineering & translational medicine2025

Transport physics-informed reinforcement learning agents deployed in standalone infusion pumps for managing multidrug delivery in critical care.

V Chandran Suja, A L H S Detry, N M Sims, D E Arney, S Mitragotri, R A Peterfreund

Abstract read
In one paragraph

Article in Bioengineering & translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

V Chandran SujaSchool of Engineering and Applied Sciences Harvard University Boston Massachusetts USA.ORCID https://orcid.org/0000-0002-3406-7655
A L H S DetryDepartment of Anesthesia, Critical Care and Pain Medicine Massachusetts General Hospital Boston Massachusetts USA.
N M SimsDepartment of Anesthesia, Critical Care and Pain Medicine Massachusetts General Hospital Boston Massachusetts USA.
D E ArneyDepartment of Anesthesia, Critical Care and Pain Medicine Massachusetts General Hospital Boston Massachusetts USA.
S MitragotriSchool of Engineering and Applied Sciences Harvard University Boston Massachusetts USA.
R A PeterfreundDepartment of Anesthesia, Critical Care and Pain Medicine Massachusetts General Hospital Boston Massachusetts USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Managing delivery of complex multidrug infusions in anesthesia and critical care presents a significant clinical challenge. Current practices relying on manual control of infusion pumps often result in unpredictable drug delivery profiles and dosing errors-key issues highlighted by the United States Food and Drug Administration (FDA). To address these issues, we introduce the SMART (synchronized-pump management algorithms for reliable therapies) framework, a novel approach that leverages low Reynolds number drug transport physics and machine learning to accurately manage multidrug infusions in real-time. SMART is activated based on the Shafer number (

Indexed as

advection diffusion equationdrug deliveryphysics‐informed machine learningreinforcement learning

Identifiers

PMID41030275
PMCPMC12478332

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.