Evidence map›Paper›PMID 41030270›Full record

ArticleFrontiers in medicine2025

Ultra-late relapse of acute promyelocytic leukemia 18 years after complete remission: a case report and literature review.

Lu Gao, Yang An, Qian Li, Shuo Shi, Jie Zhou, Zuochen Du, Pei Huang, Mingqiang Ren, Yan Chen

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lu Gao *Department of Hematology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Yang An *Department of Pediatrics, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Qian LiDepartment of Pediatrics, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Shuo ShiDepartment of Pediatrics, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Jie ZhouDepartment of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Zuochen DuDepartment of Pediatrics, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Pei HuangDepartment of Pediatrics, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Mingqiang RenDepartment of Hematology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Yan ChenDepartment of Pediatrics, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Late relapse of acute promyelocytic leukemia (APL) is associated with high mortality rates. While APL typically shows a low incidence of relapse after achieving complete remission (CR) for more than 7 years, we report a rare case of APL relapse occurring 18 years after CR was achieved. The patient was successfully treated with a combination of arsenic trioxide (ATO) and all-trans retinoic acid (ATRA), leading to favorable outcomes. Additionally, we review our treatment experience and provide a comprehensive analysis of the existing literature, summarizing the characteristics of reported APL cases that relapsed after maintaining CR for over 7 years.

Indexed as

acute promyelocytic leukemiaall-trans retinoic acidarsenic trioxideCase Report and Literature Reviewultra-late relapse

Identifiers

PMID41030270
PMCPMC12477033

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.