ArticleFrontiers in medicine2025
Effects of pressure-controlled ventilation-volume guaranteed on children undergoing thoracic surgery: a prospective, randomized controlled trial.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Background: Children have higher morbidity and mortality than adults during thoracic surgery with one-lung ventilation (OLV), reducing the incidence may in part be achieved by the use of appropriate mechanical ventilation mode. This study evaluated whether pressure-controlled ventilation-volume guaranteed (PCV-VG) reduces intrapulmonary shunt (Qs/Qt) and ventilator-induced lung injury (VILI) in pediatric patients. Methods: Eighty children underwent thoracic surgery requiring OLV were randomly divided into PCV-VG group and volume-controlled ventilation (VCV) group. The PCV-VG group utilized the PCV-VG during surgery, whereas the other group employed the VCV. The parameter settings during two-lung and OLV were consistent between the groups. The primary outcome comprised the Qs/Qt fraction. The secondary outcomes encompassed respiratory parameters, blood gas analysis results, the occurrence of postoperative pulmonary complications (PPCs), and more. Results: Following PCV-VG implementation, the median Qs/Qt during OLV exhibited a significant improvement (18.2 to 12.7 at T2, 11.4 to 9.1 at T3, Conclusion: Implementation of PCV-VG for children undergoing thoracic surgery demonstrated significant benefits. It can improve Qs/Qt, increase oxygenation, reduce airway pressure, and alleviate VILI during OLV. Clinical trial registration: Clinicaltrials.gov, identifier ChiCTR2200065237.
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