ArticlePharmacology research & perspectives2025
Sex-Dependent Long-Term Neurobehavioral Recovery in Experimental Neonatal Hypoxic-Ischemic Encephalopathy.
Article in Pharmacology research & perspectives, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Neuroimmune responses in neonatal hypoxic-ischemic encephalopathy: cellular roles, crosstalk, and therapeutic opportunities.Frontiers in pediatrics · 2026Review
- Sex-Dependent Long-Term Neurobehavioral Recovery in Experimental Neonatal Hypoxic-Ischemic Encephalopathy.Pharmacology research & perspectives · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
This study investigates the sex-dependent effects of therapeutic hypothermia and a neuroprotectant (CHF6467) on long-term neurobehavioral recovery in neonatal rats subjected to hypoxic-ischemic encephalopathy. Using the Rice-Vannucci model, rats were divided into five groups: sham lesion, hypoxic-ischemic insult, hypoxic-ischemic insult with CHF6467, hypoxic-ischemic insult with hypothermia, and hypoxic-ischemic insult with CHF6467 combined with hypothermia. Behavioral tests at postnatal day 30 (P30) and 60 (P60) revealed significant improvements in motor coordination and spatial memory in treated groups compared to the vehicle-treated group, associated with reductions in infarct size at P60. Notably, female rats exhibited superior motor coordination recovery compared to males, despite similar neuroprotection levels. This suggests that motor coordination recovery is not solely dependent on the extent of neuronal damage. Conversely, spatial memory impairment was sex-independent and closely associated with the degree of neuroprotection. These findings highlight the importance of considering sex differences in neuroprotective treatment efficacy and suggest potential variations in responses between males and females in clinical settings.
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Registered trials
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