Evidence map›Paper›PMID 41030139›Full record

ArticleClinical transplantation and research2025

Refractory antibody-mediated rejection after high-emergency lung transplantation for dermatomyositis with anti-MDA5 antibody: a case report.

Louise Chantelot, Domitille Mouren, Jean-Luc Taupin, Aurélie Cazes, Jonathan Messika, Cendrine Godet, Mathilde Salpin, Gaelle Weisenburger, Brice Lortat-Jacob, Pierre Mordant and 8 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical transplantation and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Louise ChantelotDepartment of Pneumology, Allergology and Lung Transplantation, Bichat Hospital AP-HP, Paris-Cite University, Paris, France.ORCID https://orcid.org/0009-0007-5785-2799
Domitille MourenDepartment of Pneumology, Allergology and Lung Transplantation, Bichat Hospital AP-HP, Paris-Cite University, Paris, France.ORCID https://orcid.org/0000-0002-4134-4737
Jean-Luc TaupinDepartment of Immunology and Histocompatibility, Saint Louis Hospital AP-HP, Paris-Cite University, Paris, France.ORCID https://orcid.org/0000-0002-5766-046X
Aurélie CazesDepartment of Pathology, Bichat Hospital AP-HP, Paris-Cite University, Paris, France.ORCID https://orcid.org/0000-0002-7172-9101
Jonathan MessikaDepartment of Pneumology, Allergology and Lung Transplantation, Bichat Hospital AP-HP, Paris-Cite University, Paris, France.ORCID https://orcid.org/0000-0003-2123-3527
Cendrine GodetDepartment of Pneumology, Allergology and Lung Transplantation, Bichat Hospital AP-HP, Paris-Cite University, Paris, France.ORCID https://orcid.org/0000-0002-9627-3016
Mathilde SalpinDepartment of Pneumology, Allergology and Lung Transplantation, Bichat Hospital AP-HP, Paris-Cite University, Paris, France.ORCID https://orcid.org/0000-0002-0110-1589
Gaelle WeisenburgerDepartment of Pneumology, Allergology and Lung Transplantation, Bichat Hospital AP-HP, Paris-Cite University, Paris, France.ORCID https://orcid.org/0000-0002-1357-9686
Brice Lortat-JacobDepartment of Anaesthesiology and Critical Care Medicine, Bichat Claude Bernard Hospital, Université Paris Cité, Paris, France.ORCID https://orcid.org/0000-0001-7182-3678
Pierre MordantDepartment of Thoracic Surgery, Bichat Claude Bernard Hospital, Université Paris Cité, Paris, France.ORCID https://orcid.org/0000-0001-5716-4848
Jean-François AlexandraDepartment of Internal Medicine, Bichat Hospital AP-HP, Paris-Cite University, Paris, France.ORCID https://orcid.org/0000-0003-3499-7534
Raphael BorieDepartment of Pneumology, Allergology and Lung Transplantation, Bichat Hospital AP-HP, Paris-Cite University, Paris, France.ORCID https://orcid.org/0000-0002-9906-0024
Chloé ComarmondDepartment of Internal Medicine and Clinical Immunology, Lariboisière Hospital, Paris-Cite University, Paris, France.ORCID https://orcid.org/0000-0002-0990-8213
Yves AllenbachDepartment of Internal Medicine and Clinical Immunology, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.ORCID https://orcid.org/0000-0002-3185-7993
Yurdagül UzunhanDepartment of Pneumology, Avicenne Hospital AP-HP, Sorbonne Paris Nord University, Bobigny, France.ORCID https://orcid.org/0000-0002-1607-1407
Hervé MalDepartment of Pneumology, Allergology and Lung Transplantation, Bichat Hospital AP-HP, Paris-Cite University, Paris, France.ORCID https://orcid.org/0000-0002-5951-436X
Antoine RouxDepartment of Pneumology, Foch Hospital, Suresnes, France.ORCID https://orcid.org/0000-0003-2387-0669
Vincent BunelDepartment of Pneumology, Allergology and Lung Transplantation, Bichat Hospital AP-HP, Paris-Cite University, Paris, France.ORCID https://orcid.org/0000-0002-5080-6331

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case report describes a female with amyopathic anti-MDA5+ dermatomyositis who underwent emergency double lung transplantation due to rapidly progressive interstitial lung disease. Following transplantation, she developed acute antibody-mediated rejection (AMR). Despite multiple rounds of immunosuppressive therapy, her condition continued to deteriorate, and her donor-specific anti-human leukocyte antigen antibody levels increased markedly. An experimental treatment, imlifidase-an immunoglobulin G endopeptidase-was employed as a rescue therapy. This case highlights the complexity of posttransplant management of AMR and emphasizes the need for dedicated clinical trials to provide additional data.

Indexed as

Antibody-mediated rejectionAnti-MDA5 antibodyDermatomyositisEmergencyLung transplantation

Identifiers

PMID41030139
PMCPMC12783003

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.