ArticleBrain and behavior2025
Stereo-Electroencephalography Reveals Dynamic Spatio-Spectral Signatures of Negative Emotions: A Distributed Circuit Mechanism Involving Amygdala-Cingulate-Hippocampus-Orbitofrontal Networks.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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7 authors.
Funding
Abstract
backgroundThe brain functional network connection mechanism mediating negative emotions is a central research focus in affective neuroscience. Although prior studies have identified key regions involved in emotion processing, the dynamic interactions among these regions remain inadequately understood.
methodsIn this study, stereo-electroencephalography (SEEG) was employed to simultaneously record local field potentials from both human cortical and subcortical structures. This technique enables the tracking of dynamic time-frequency responses and functional connectivity patterns evoked by emotional stimuli with high spatial and temporal resolution.
resultsThe findings indicate that the amygdala (Amy), anterior cingulate cortex (ACC), hippocampus (Hip), and orbitofrontal cortex (OFC) play pivotal roles in negative emotion processing. Importantly, the experience of negative emotions depends on dynamic network interactions among these regions.
conclusionThis study provides direct electrophysiological evidence supporting previous investigations of emotional neural circuits based on electroencephalography (EEG) and functional magnetic resonance imaging (fMRI). Furthermore, it offers novel insights into the real-time network mechanisms underlying emotion processing.
trial registrationChinese Clinical Trial Registry: ChiCTR2400080217.
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