Evidence map›Paper›PMID 41030074›Full record

ArticleNano letters2025

Noninvasive Optoacoustic Imaging of Oxygen Saturation Reveals Hypoxic Hematopoietic Bone Marrow during Systemic Inflammation.

Ashish Tiwari, Narmeen Haj, Ruth Pikovsky, Shirly Hagay, Maria Berihu, Betsalel Elgrably, Liron McLey, Majd Machour, Shiri Karni-Ashkenazi, Inbar Brosh and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nano letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ashish TiwariFaculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel.ORCID 0000-0001-8520-1829
Narmeen HajFaculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
Ruth PikovskyFaculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
Shirly HagayFaculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
Maria BerihuFaculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
Betsalel ElgrablyFaculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
Liron McLeyFaculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
Majd MachourFaculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
Shiri Karni-AshkenaziFaculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
Inbar BroshFaculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
Shy ShohamNYU Langone Health, Tech4Health and Neuroscience Institutes, and Department of Ophthalmology, New York, New York 10016, United States.
Shulamit LevenbergFaculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel.ORCID 0000-0001-5471-7339
Daniel RazanskyFaculty of Medicine, University of Zurich, Zurich 8057, Switzerland.
Amir RosenthalFaculty of Electrical Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
Katrien VandoorneFaculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel.ORCID 0000-0002-8132-8280

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation drives various diseases, including cardiovascular, neurodegenerative, and oncological disorders, by altering immune cell dynamics in hematopoietic niches. The bone marrow is the primary site for hematopoietic stem and progenitor cell activity. Here, we present a novel, noninvasive approach using multispectral optoacoustic tomography (MSOT) to track oxygenation dynamics in the murine calvarial bone marrow during acute systemic inflammation induced by lipopolysaccharide (LPS). Our MSOT system provided real-time, label-free imaging of hemoglobin oxygen saturation (sO

Indexed as

Bone MarrowHypoxiaInflammationOxygenOxygen SaturationPhotoacoustic TechniquesAnimalsHematopoietic Stem CellsLipopolysaccharidesMiceMice, Inbred C57BLLipopolysaccharidesOxygenBone marrowHypoxiaInflammationLipopolysaccharidesOptoacoustic imagingOxygenation

Identifiers

PMID41030074
PMCPMC12893716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.