ReviewDrug delivery2025
Nucleic acid-encoded antibody gene transfer-next generation of antibody therapies.
Review in Drug delivery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- mRNA-Encoded Antibodies: An Emerging Paradigm in Antiviral Protection.Biomolecules · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibody therapeutics have emerged as a cornerstone in modern biopharmaceutical development, revolutionizing treatments across diverse diseases. Recent breakthroughs in antibody discovery technologies, particularly single B-cell sorting and high-throughput sequencing, have significantly enhanced the ability to identify and isolate potent therapeutic antibodies. Despite these advances, widespread adoption of monoclonal antibody (mAb) therapies faces substantial challenges, including complex manufacturing processes, high production costs, and stringent cold-chain storage requirements. A promising solution to these limitations is nucleic acid-encoded antibody delivery, which enables in vivo production of functional antibodies. This technology delivers nucleotide sequences encoding mAbs instead of the antibody proteins themselves, effectively turning the body into a bioreactor for antibody production. By bypassing the complex purification and quality control processes associated with traditional recombinant protein production, this approach offers a more streamlined and potentially cost-effective alternative. Herein, we review current nucleic acid-based antibody delivery platforms, highlighting the unique advantages and technical challenges. We provide an in-depth analysis of the latest advancements in this field, including both viral and non-viral delivery methods, and discuss their implications for next-generation antibody therapeutics. We also examine the potential applications in infectious diseases and cancer immunotherapy, alongside regulatory and safety considerations for clinical translation. We aim to provide valuable insights and guidance for researchers and clinicians in advancing novel antibody-based therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.