ArticleAnnals of medicine2025
Stratified and propensity score matching analysis of the effectiveness of fibrin glue in preventing postoperative bleeding after endoscopic submucosal dissection.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of Fibrin Sealants and Polyglycolic Acid Sheets in Reducing Postoperative Hemorrhage Following Gastric Endoscopic Submucosal Dissection: A Meta-analysis of Randomized and Observational Studies.Journal of gastrointestinal cancer · 2026Pooled it
- A pilot study on the efficacy of cyanoacrylate glue in preventing post-ESD bleeding at the gastric angle.Surgical endoscopy · 2026Article
- Adjunctive fibrin glue for the prevention of bleeding after endoscopic submucosal dissection of gastroesophageal lesions: a systematic review and meta-analysis.Surgical endoscopy · 2026Article
- Establishment and validation of a predictive scoring system for titanium clip retention at six months after endoscopic submucosal dissection for gastric lesions.Scientific reports · 2026Article
- Predicting post-ESD bleeding in elderly patients with early gastrointestinal cancer: an explainable model based on endoscopic features.Frontiers in medicine · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndoscopic submucosal dissection (ESD) is a commonly used treatment for superficial lesions of the upper gastrointestinal tract, of which the most common complication is postoperative bleeding. This retrospective study mainly aimed at assessing the effect of intraoperative fibrin glue (FG) spraying on postoperative bleeding in patients with early esthe ophageal cancer (EEC) and early gastric cancer (EGC).
methodsA retrospective analysis of FG uses during ESD was conducted in 362 patients with early upper gastrointestinal malignancy. 362 patients who received ESD were divided into the FG group and the conventional group, comparing their postoperative bleeding rate, acute postoperative bleeding rate, and delayed postoperative bleeding rate using stratified analysis and propensity score matching (PSM) to eliminate potential confounding factors. Univariate and multivariate logistic regression were implemented to investigate the risk variables for surgical hemorrhage following early upper gastrointestinal malignancy.
resultsThe results of stratification based on intraoperative bleeding showed that the use of FG in the intraoperative bleeding group of EGC patients undergoing ESD could effectively reduce bleeding within 48 h after surgery (
conclusionsIntraoperative spraying of FG may help to reduce the incidence of postoperative bleeding after ESD, especially acute postoperative bleeding in patients with EGC.
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